Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis

X Li, S Wei, S Niu, X Ma, H Li, M Jing, Y Zhao - Computers in biology and …, 2022 - Elsevier
Abstract Background Huanglian Jiedu Decoction (HLJDD) is a classical herbal formula with
potential efficacy in the treatment of sepsis. However, the main components and potential …

Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents

A Najmi, SA Javed, M Al Bratty, HA Alhazmi - Molecules, 2022 - mdpi.com
Natural products represents an important source of new lead compounds in drug discovery
research. Several drugs currently used as therapeutic agents have been developed from …

A Comprehensive Review on Cannabis sativa Ethnobotany, Phytochemistry, Molecular Docking and Biological Activities

S Hourfane, H Mechqoq, AY Bekkali, JM Rocha… - Plants, 2023 - mdpi.com
For more than a century, Cannabis was considered a narcotic and has been banned by
lawmakers all over the world. In recent years, interest in this plant has increased due to its …

The role and potential of computer-aided drug discovery strategies in the discovery of novel antimicrobials

SO Oselusi, P Dube, AI Odugbemi, KA Akinyede… - Computers in biology …, 2024 - Elsevier
Antimicrobial resistance (AMR) has become more of a concern in recent decades,
particularly in infections associated with global public health threats. The development of …

Using Network Pharmacology and Molecular Docking to Explore the Mechanism of Shan Ci Gu (Cremastra appendiculata) Against Non-Small Cell Lung Cancer

Y Wang, Y Zhang, Y Wang, X Shu, C Lu, S Shao… - Frontiers in …, 2021 - frontiersin.org
Background: In recent years, the incidence and mortality rates of non-small cell lung cancer
(NSCLC) have increased significantly. Shan Ci Gu is commonly used as an anticancer drug …

Immune-Enhancing Effects of a Novel Glucan from Purple Sweet Potato Ipomoea batatas (L.) Lam on RAW264.7 Macrophage Cells via TLR2- and TLR4-Mediated …

C Ji, Z Zhang, J Chen, D Song, B Liu, J Li… - Journal of Agricultural …, 2021 - ACS Publications
PSPP-1 was obtained from purple sweet potato, and the effects of PSPP-1 on the immune
modulation on macrophage cells were investigated for the first time. PSPP-1 promoted …

[PDF][PDF] Natural Products As Sources of Drug Discovery: Exploration, Optimisation, and Translation Into Clinical Practice

S Mandal, NR Kar, AV Jain, P Yadav - African J Biol Sci (South Africa), 2024 - afjbs.com
This paper features the significance of regular items in drug disclosure, featuring their
assorted synthetic designs and natural exercises. It underscores the requirement for a …

Applying molecular docking to pesticides

Y Hou, Y Bai, C Lu, Q Wang, Z Wang… - Pest Management …, 2023 - Wiley Online Library
Pesticide creation is related to the development of sustainable agricultural and ecological
safety, and molecular docking technology can effectively help in pesticide innovation. This …

Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4

J Yan, F Ye, Y Ju, D Wang, J Chen, X Zhang, Z Yin… - Cell Calcium, 2021 - Elsevier
Psoriasis is an immune-mediated chronic inflammatory skin disease characterized by
erythema, scales, and infiltration of the skin, which causes deleterious effects on patient …

Potential Antioxidative and Anti-Hyperuricemic Components Targeting Superoxide Dismutase and Xanthine Oxidase Explored from Polygonatum Sibiricum Red.

J Li, Z Wang, M Fan, G Hu, M Guo - Antioxidants, 2022 - mdpi.com
Polygonatum sibiricum Red.(P. sibiricum) has been used as a traditional Chinese medicine
with a wide range of pharmacology effects. However, the responsible bioactive compounds …