The evaluation and regulation of chemical substances have undergone a major overhaul in
Canada, the USA and the European Union (EU) over the last decade. To facilitate …

Computational toxicology is a sub-discipline of toxicology concerned with the development
and use of computer-based models and methodology to understand and predict chemical …

Toxicology in the 21st century (Tox21) is a consortium of five government agencies that set
out to advance high-throughput screening while transitioning from mammalian model …

The expression of some microRNAs (miRNA) is modulated in response to cigarette smoke
(CS), which is a leading cause of major preventable diseases. However, whether miRNA …

Analytic “'omic” techniques and systems biology driven bioinformatics have increasingly
been a game changer in the study of herbal drugs, thanks to the simultaneous detection of …

We hypothesized that typical tissue and clinical chemistry (ClinChem) end points measured
in rat toxicity studies exhibit chemical-independent biological thresholds beyond which …

Assessment and characterization of toxicological properties of chemicals, active
pharmaceutical ingredients, and drugs are essential for the safety of human health and the …

Traditional methods for cancer risk assessment are retrospective, resource-intensive, and
not feasible for the vast majority of environmental chemicals. In earlier studies, we used a set …

Neurotoxicants may be widespread in the environment and can produce serious health
impacts in the human population. Screening programs that use in vitro methods have …

In-vivo toxicity assessment is an important step prior to clinical development and is still the
main source of data for overall risk assessment of a new molecular entity (NCE). All in-vivo …