In today's world, there is an unprecedented rise in the prevalence of chronic metabolic
diseases, including obesity, insulin resistance and type 2 diabetes (T2D). The pathogenesis …

It is well recognized that humans are enjoying longer life spans than their ancestors.
However, longevity has resulted in a larger geriatric population worldwide, posing an …

According to the Developmental Origins of Health and Disease hypothesis intrauterine or
postnatal adaptations to the environment causes morphologic, physiologic or metabolic …

Abstract The Developmental Origins of Health and Disease hypothesis formulated in the
early 1990s has stimulated research on long-term effects of early nutrition and environment …

DNA methylation age acceleration, the discrepancy between epigenetic age and
chronological age, is associated with mortality and chronic diseases, including diabetes …

Methotrexate (MTX) is administered to treat childhood acute lymphoblastic leukemia (ALL). It
acts by inhibiting dihydrofolate reductase which reduces methyltetrahydrofolate, a key …

The epigenetic profile of the developing fetus is sensitive to environmental influence.
Maternal diet has been shown to influence DNA methylation patterns in offspring, but …

Epigenetic modifications, such as DNA methylation, can be regulated by nutrition and
dietary factors. There has been a large increase in the use of sustainable plant-based …

There is growing support that environmental influences and individual genetic susceptibility
may increase the incidence and accelerate the onset of Alzheimer's disease (AD) …

DNA methylation reactions are regulated, in the first instance, by enzymes and the
intermediates that constitute the 'so called'one-carbon metabolism. This is a complex …