Hox genes, a highly conserved subgroup of the homeobox superfamily, have crucial roles in
development, regulating numerous processes including apoptosis, receptor signalling …

Many cancers seem to depend on a small population of'cancer stem cells' for their continued
growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be …

In acute myeloid leukemia (AML), therapy resistance frequently occurs, leading to high
mortality among patients. However, the mechanisms that render leukemic cells drug …

Neuroblastoma is an embryonal malignancy of the sympathetic nervous system.
Spontaneous regression and differentiation of neuroblastoma is observed in a subset of …

AKT activation is associated with many malignancies, where AKT acts, in part, by inhibiting
FOXO tumor suppressors. We show a converse role for AKT/FOXOs in acute myeloid …

Myeloid malignancies are clonal disorders that are characterized by acquired somatic
mutation in hematopoietic progenitors. Recent advances in our understanding of the genetic …

Chromosomal rearrangements involving the H3K4 methyltransferase mixed-lineage
leukemia (MLL) trigger aberrant gene expression in hematopoietic progenitors and give rise …

The mixed-lineage leukemia (MLL1/ALL-1/HRX) histone methyltransferase is involved in the
epigenetic maintenance of transcriptional memory and the pathogenesis of human …

Notch signaling pathway activation is known to contribute to the pathogenesis of a spectrum
of human malignancies, including T cell leukemia. However, recent studies have implicated …

The SH2-containing tyrosine phosphatase Shp2 (PTPN11) is required for growth factor and
cytokine signaling. Germline Shp2 mutations cause Noonan Syndrome (NS), which is …