The construction of C− C bonds with complete control of the stereochemical course of a
reaction is of utmost importance for organic synthesis. The aldol reaction—the simple …

The aldol reaction is one of the most important methods for the stereoselective construction
of polyketide natural products, not only for nature but also for synthetic chemistry. The …

In every natural product synthesis endeavor, chemists charting their way toward the target
molecule have to face both foreseeable problems as well as unexpected difficulties. 1 Of the …

Various chiral oxazolidinones (Evans' oxazolidinones) have been employed as effective
chiral auxiliaries in the asymmetric alkylation of different enolates. This strategy has been …

1. Introduction 2. Reductive Desulfonylation 2.1. Replacement of the sulfone group by
hydrogen 2.1. 1. Alkyl sulfones 2.1. la ct-Functionalised alkyl sulfones 2.1. 1. b. Other …

Marine organisms, particularly sponge invertebrates and associated bacteria, are
enormously rich sources of structurally diverse secondary metabolites with unique molecular …

With modern methods for asymmetric catalysis breaking ground, the use of chiral auxiliaries
seems to be old-fashioned and rather inefficient. However, for many transformations, chiral …

Die Knüpfung von C‐C‐Bindungen unter vollständiger Kontrolle des stereochemischen
Verlaufs einer Reaktion ist in der organischen Synthesechemie von großer Bedeutung. Die …

A novel tandem metal relay catalytic system was developed by combining gold-catalyzed
cycloisomerization with an early transition-metal-catalyzed inverse-electron-demand hetero …

Cambridge, MA 02138 (USA) Fax: Int. code+(617) 495-1460 e-mail: evans@ chemistry.
harvard. edu [** I Financial support has been provided by the National Institutes of Health …