The synthesis of the marine neurotoxin azaspiracid-1 has been accomplished. The
individual fragments were synthesized by catalytic enantioselective processes: A hetero …

A mild, stereoselective method for the Ni-catalyzed synthesis of α-C-alkylglycosides is
reported. This approach entails the reductive coupling of glycosyl bromides with activated …

Efficient construction of architecturally complex natural and unnatural products is the
hallmark of organic chemistry. Anion relay chemistry (ARC)—a multi-component coupling …

The synthesis of the C-1− C-28 ABCD fragment of spongistatin is described. Anti-selective
boron-mediated aldol coupling of a CD spiroketal ketone fragment to an AB spiroketal …

Modern science has developed well-defined and versatile sets of chemicals to perform
many specific tasks, yet the diversity of these reagents is so large that it can be impractical …

The total synthesis of spongistatin 1 (1) and spongistatin 2 (2) has been achieved through
an advanced-stage intermediate. The synthesis is highlighted by a highly convergent …

The spongistatins comprise an important family of architecturally complex marine macrolides
that display extraordinary antitumor activities against a variety of human cancer cell lines …

A blueprint for controlling the stereochemistry of oxygenated 5, 5-spiroketals using chelation
effects is provided. Chelation specifically of zinc salts (other protic and Lewis acids were less …

The design and synthesis of spiroketal structures and their chemical modification, leading to
a collection of new small molecules for biological evaluation as orally-bioavailable lead …

The identification of Yb (OTf) 3 through a multivariable high-throughput experimentation
strategy has enabled a unified protocol for the direct conversion of enantioenriched N …