Studies in Marine Maerolide Synthesis: Synthesis of a Fully Functionalised C1-C28 Subunit of
Spongistatin 1 (Altohyrtin A) Page 1 TETRAHEDRON LETTERS Tetrahedron Letters 39 (1998) …

The densely funkctionalized C38− C44 segment F of altohyrtin A with its five contiguous
stereogenic centers was prepared in 10 steps and in 28% overall yield (two steps per …

A growing number of complex polyketides, isolated from a variety of marine and terrestrial
sources, present novel scaffolds for the development of cancer therapeutic agents. However …

Chiral allylsilane 2 reacted with chiral α-substituted aldehydes to afford the corresponding 1,
4-syn-products with good diastereoselectivities. The best selectivities are observed when …

A synthesis of the C17 C18 segment of altohyrtin A is reported. The synthesis uses a
coupling step between two chiral subunits, both of which were synthesized from L-malic …

The CD-spiroacetal containing C16–C28 subunit 2, as used in the total synthesis of the
potent cytotoxic macrolide, altohyrtin A (spongistatin 1), was prepared by an alternative route …

An effcient and highly diastereoselective 12 step synthesis of the C (36)–C (45) subunit (2a)
of spongistatin 1 is described. The synthesis features highly diastereoselective α …

Spongistatin 1 is among the most potent anti-proliferative agents ever discovered rendering
it an attractive candidate for development as a payload for antibody–drug conjugates and …

The stereoselective total synthesis of the spiroketal containing Streptomyces metabolite (−)‐
spirofungin A (1) is described. A key step involved a spiroketalisation controlled by an …

The hydroxyethylene dipeptide isosteres l-682,679, l-684,414, l-685,434, and l-685,458
were synthesized in a few steps by a sequence involving an allyltrichlorostannane coupling …