Utilizing artificial intelligence (AI) in drug design represents an advanced approach for
identifying targets and developing new drugs. Integrating AI techniques significantly reduces …

This Perspective is the eighth in an annual series that summarizes successful fragment-to-
lead (F2L) case studies published each year. A tabulated summary of relevant articles …

The introduction of biologic agents for the treatment of psoriasis has revolutionized the
current treatment landscape, targeting cytokines in the interleukin (IL)-23/IL-17 pathway and …

Background As a member of the Janus kinase (JAK) family, which includes JAK1, JAK2 and
JAK3, tyrosine kinase 2 (TYK2) plays an important role in signal transduction and immune …

Tyrosine kinase 2 (TYK2) mediates cytokine signaling through type 1 interferon, interleukin
(IL)-12/IL-23, and the IL-10 family. There appears to be an association between TYK2 …

High-quality predicted structures enable structure-based approaches to an expanding
number of drug discovery programs. We propose that by utilizing free energy perturbation …

Introduction The use of the current available therapies for psoriasis management may be
sometimes limited by reduced patients' compliance, safety issues for patients' comorbidities …

Psoriasis is a chronic inflammatory disease that affects 2% to 3% of the global population,
with a considerable impact on patients' quality of life. 1 Current US Food and Drug …