For oral drugs, the formulator and discovery chemist have a tool available to them that can
be used to navigate the risks associated with the selection and development of immediate …

Pulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry
powder inhalers (DPIs) are convenient, portable and environmentally friendly devices …

Ideal controlled pulmonary drug delivery systems provide sustained release by retarding
lung clearance mechanisms and efficient lung deposition to maintain therapeutic …

Hydrogels warrant attention as a potential material for use in sustained pulmonary drug
delivery due to their swelling and mucoadhesive features. Herein, hyaluronic acid (HA) is …

In vitro dissolution and permeability testing aid the simulation of the in vivo behavior of
inhalation drug products. Although the regulatory bodies have specific guidelines for the …

A new modelling approach for dissolution of polydisperse powders is developed within the
framework of the classical Noyes–Whitney/Nernst–Brunner analysis. Its distinguishing …

Dissolution rate impacts the absorption rate of poorly soluble inhaled drugs. In vitro
dissolution tests that can capture the impact of changes in critical quality attributes of the …

The dissolution of inhaled drug particles in the lungs is a challenge to model using
biorelevant methods in terms of (i) collecting a respirable emitted aerosol fraction and …

The claimed functional basis for ICSs in asthma and COPD is airway selectivity, attained by
inhaling a potent, lipophilic compound with long local dissolution/absorption time. The …

Many inhaled drugs are poorly water soluble, and the dissolution rate is often the rate-
limiting step in the overall absorption process. To improve understanding of pulmonary drug …