The vascular endothelium regulates blood flow in response to physiological needs.
Endothelial dysfunction is closely related to atherosclerosis and its risk factors, and it …

Although substantial improvements have been made in majority of cardiac disorders, heart
failure (HF) remains a major health problem, with both increasing incidence and prevalence …

Cardiovascular disease is a major cause of mortality and morbidity. Current research
investigating the roles of nitric oxide (NO) with relevance to the cardiovascular system is an …

Accumulating evidence has demonstrated the importance of reactive oxygen species (ROS)
as an essential second messenger in health and disease. Endothelial dysfunction is the …

Hypertension is a complex and multifaceted disease, and there are well established sex
differences in many aspects of blood pressure (BP) control. The intent of this review is to …

2498 MARON BA et al. tion of eNOS is dynamically regulated9 and the enzyme is thus
exposed to different concentrations of ROS depending upon where in the cell the protein is …

Background—Ceruloplasmin (Cp) decreases nitric oxide bioavailability in blood and has
been associated with cardiovascular disease (CVD) in clinical studies. We assessed the …

Hypertension and abdominal aortic aneurysm (AAA) are severe cardiovascular diseases
with incompletely defined molecular mechanisms. In the current study we generated …

It is well documented that metabolic syndrome (ie a group of risk factors, such as abdominal
obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides …

Several studies indicate that oxidative stress might play a central role in the initiation and
maintenance of cardiovascular diseases. It remains unclear whether ceruloplasmin acts as a …