Diabetic nephropathy (DN) is a common microvascular complication in the late stages of
diabetes. Currently, the etiology and pathogenesis of DN are not well understood. Even so …

Acute kidney injury (AKI) is a serious clinical disease that is mainly caused by renal
ischemia-reperfusion (I/R) injury, sepsis, and nephrotoxic drugs. The pathologic mechanism …

The evolutionary conserved Wnt signaling transduction pathway plays essential roles in a
wide array of biologic processes including embryonic development, branching …

Background Despite lack of clinical therapy in acute kidney injury (AKI) or its progression to
chronic kidney disease (CKD), administration of growth factors shows great potential in the …

Diabetic nephropathy is a common complication in diabetes, but still lack of effective
therapeutic strategies. This study aimed to investigate the therapeutic effect of basic …

Renal ischemia-reperfusion (I/R) injury is one of the major causes of acute kidney injury.
However, there is still no effective treatment for this disease. Basic fibroblast growth factor …

C1q/tumor necrosis factor-related protein 6 (CTRP6), a member of CTRPs family, was
involved in fibrosis. However, the biological function of CTRP6 in renal fibrosis remains …

Non-alcoholic steatohepatitis (NASH) is associated with intrahepatic lipid accumulation,
inflammation, and hepatocyte death. Several studies have indicated that high-fat diets …

Myocardial infarction (MI) is known as a main cardiovascular disease that leads to extensive
cell death by destroying vasculature in the affected cardiac muscle. The development of …

Basic fibroblast growth factor (bFGF) has shown great therapeutic effects for diabetic
nephropathy (DN). However, its clinical applications are limited due to its short half-life, low …