Towards a youth mental health paradigm: a perspective and roadmap
Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
Impact of early life stress on reward circuit function and regulation
Early life stress–including experience of child maltreatment, neglect, separation from or loss
of a parent, and other forms of adversity–increases lifetime risk of mood, anxiety, and …
of a parent, and other forms of adversity–increases lifetime risk of mood, anxiety, and …
An increase of inhibition drives the developmental decorrelation of neural activity
Throughout development, the brain transits from early highly synchronous activity patterns to
a mature state with sparse and decorrelated neural activity, yet the mechanisms underlying …
a mature state with sparse and decorrelated neural activity, yet the mechanisms underlying …
Unsupervised spatially embedded deep representation of spatial transcriptomics
Optimal integration of transcriptomics data and associated spatial information is essential
towards fully exploiting spatial transcriptomics to dissect tissue heterogeneity and map out …
towards fully exploiting spatial transcriptomics to dissect tissue heterogeneity and map out …
Spatial transcriptomics reveals the distinct organization of mouse prefrontal cortex and neuronal subtypes regulating chronic pain
A Bhattacherjee, C Zhang, BR Watson… - Nature …, 2023 - nature.com
The prefrontal cortex (PFC) is a complex brain region that regulates diverse functions
ranging from cognition, emotion and executive action to even pain processing. To decode …
ranging from cognition, emotion and executive action to even pain processing. To decode …
Adolescence is a sensitive period for prefrontal microglia to act on cognitive development
SM Schalbetter, AS von Arx, N Cruz-Ochoa… - Science …, 2022 - science.org
The prefrontal cortex (PFC) is a cortical brain region that regulates various cognitive
functions. One distinctive feature of the PFC is its protracted adolescent maturation, which is …
functions. One distinctive feature of the PFC is its protracted adolescent maturation, which is …
[HTML][HTML] The dual hit hypothesis of schizophrenia: Evidence from animal models
Schizophrenia is a heterogeneous psychiatric disorder, which can severely impact social
and professional functioning. Epidemiological and clinical studies show that schizophrenia …
and professional functioning. Epidemiological and clinical studies show that schizophrenia …
Exercise types and working memory components during development
Working memory is crucial to learning and academic success. Exercise has been found to
benefit working memory in late life, but its effects during cognitive development are less …
benefit working memory in late life, but its effects during cognitive development are less …
Neurodevelopmental disorders—high-resolution rethinking of disease modeling
K Khodosevich, CM Sellgren - Molecular Psychiatry, 2023 - nature.com
Neurodevelopmental disorders arise due to various risk factors that can perturb different
stages of brain development, and a combinatorial impact of these risk factors programs the …
stages of brain development, and a combinatorial impact of these risk factors programs the …
Perturbation of maternal gut microbiota in mice during a critical perinatal window influences early neurobehavioral outcomes in offspring
C Morel, IM Sanchez, Y Cherifi, N Chartrel… - Neuropharmacology, 2023 - Elsevier
The gut microbiota is increasingly recognized as a key environmental factor that shapes host
development and physiology, including neural circuits formation and function. Concurrently …
development and physiology, including neural circuits formation and function. Concurrently …