STAT proteins in cancer: orchestration of metabolism
YJ Li, C Zhang, A Martincuks, A Herrmann… - Nature reviews Cancer, 2023 - nature.com
Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …
cancer, from tumour initiation through disease progression and therapy resistance, requires …
Engineering IL-2 for immunotherapy of autoimmunity and cancer
R Hernandez, J Põder, KM LaPorte… - Nature Reviews …, 2022 - nature.com
Preclinical studies of the T cell growth factor activity of IL-2 resulted in this cytokine
becoming the first immunotherapy to be approved nearly 30 years ago by the US Food and …
becoming the first immunotherapy to be approved nearly 30 years ago by the US Food and …
[HTML][HTML] Cancer therapy with TCR-engineered T cells: current strategies, challenges, and prospects
To redirect T cells against tumor cells, T cells can be engineered ex vivo to express cancer-
antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T …
antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T …
Emerging principles of cytokine pharmacology and therapeutics
Cytokines are secreted signalling proteins that play essential roles in the initiation,
maintenance and resolution of immune responses. Although the unique ability of cytokines …
maintenance and resolution of immune responses. Although the unique ability of cytokines …
[HTML][HTML] Targeting memory T cell metabolism to improve immunity
Vaccination affords protection from disease by activating pathogen-specific immune cells
and facilitating the development of persistent immunologic memory toward the vaccine …
and facilitating the development of persistent immunologic memory toward the vaccine …
Strategies to therapeutically modulate cytokine action
WJ Leonard, JX Lin - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …
functions, including development, differentiation, growth and survival. Accordingly, the …
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
Cytokines signal through cell surface receptor dimers to initiate activation of intracellular
Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy …
Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy …
IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases
The success of chimeric antigen receptor (CAR) T cell therapy in treating several
hematopoietic malignancies has been difficult to replicate in solid tumors, in part because of …
hematopoietic malignancies has been difficult to replicate in solid tumors, in part because of …
Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure
Summary Rewiring exhausted CD8+ T (Tex) cells toward functional states remains a
therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor …
therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor …
[HTML][HTML] Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages
M Tichet, S Wullschleger, A Chryplewicz, N Fournier… - Immunity, 2023 - cell.com
Immunotherapies have shown remarkable, albeit tumor-selective, therapeutic benefits in the
clinic. Most patients respond transiently at best, highlighting the importance of …
clinic. Most patients respond transiently at best, highlighting the importance of …