Artificial intelligence-driven biomedical genomics

K Guo, M Wu, Z Soo, Y Yang, Y Zhang, Q Zhang… - Knowledge-Based …, 2023 - Elsevier
As genomic research becomes more complex and data-rich, artificial intelligence (AI) has
emerged as a crucial tool for processing and analyzing high-dimensional genomic data …

A cross-study analysis of drug response prediction in cancer cell lines

F Xia, J Allen, P Balaprakash, T Brettin… - Briefings in …, 2022 - academic.oup.com
To enable personalized cancer treatment, machine learning models have been developed
to predict drug response as a function of tumor and drug features. However, most algorithm …

Distance-based support vector machine to predict DNA N6-methyladenine modification

H Zhang, Q Zou, Y Ju, C Song, D Chen - Current Bioinformatics, 2022 - ingentaconnect.com
Background: DNA N6-methyladenine plays an important role in the restriction-modification
system to isolate invasion from adventive DNA. The shortcomings of the high time …

Potent antibiotic design via guided search from antibacterial activity evaluations

L Chen, L Yu, L Gao - Bioinformatics, 2023 - academic.oup.com
Motivation The emergence of drug-resistant bacteria makes the discovery of new antibiotics
an urgent issue, but finding new molecules with the desired antibacterial activity is an …

RA-UNet: A hybrid deep attention-aware network to extract liver and tumor in CT scans

Q Jin, Z Meng, C Sun, H Cui, R Su - Frontiers in Bioengineering and …, 2020 - frontiersin.org
Automatic extraction of liver and tumor from CT volumes is a challenging task due to their
heterogeneous and diffusive shapes. Recently, 2D deep convolutional neural networks …

DRESIS: the first comprehensive landscape of drug resistance information

X Sun, Y Zhang, H Li, Y Zhou, S Shi… - Nucleic acids …, 2023 - academic.oup.com
Widespread drug resistance has become the key issue in global healthcare. Extensive
efforts have been made to reveal not only diverse diseases experiencing drug resistance …

A first computational frame for recognizing heparin-binding protein

W Zhu, SS Yuan, J Li, CB Huang, H Lin, B Liao - Diagnostics, 2023 - mdpi.com
Heparin-binding protein (HBP) is a cationic antibacterial protein derived from multinuclear
neutrophils and an important biomarker of infectious diseases. The correct identification of …

Representation of features as images with neighborhood dependencies for compatibility with convolutional neural networks

O Bazgir, R Zhang, SR Dhruba, R Rahman… - Nature …, 2020 - nature.com
Abstract Deep learning with Convolutional Neural Networks has shown great promise in
image-based classification and enhancement but is often unsuitable for predictive modeling …

DTI-CDF: a cascade deep forest model towards the prediction of drug-target interactions based on hybrid features

Y Chu, AC Kaushik, X Wang, W Wang… - Briefings in …, 2021 - academic.oup.com
Drug–target interactions (DTIs) play a crucial role in target-based drug discovery and
development. Computational prediction of DTIs can effectively complement experimental …

GraphCDR: a graph neural network method with contrastive learning for cancer drug response prediction

X Liu, C Song, F Huang, H Fu, W Xiao… - Briefings in …, 2022 - academic.oup.com
Predicting the response of a cancer cell line to a therapeutic drug is an important topic in
modern oncology that can help personalized treatment for cancers. Although numerous …