Artificial intelligence-driven biomedical genomics
As genomic research becomes more complex and data-rich, artificial intelligence (AI) has
emerged as a crucial tool for processing and analyzing high-dimensional genomic data …
emerged as a crucial tool for processing and analyzing high-dimensional genomic data …
A cross-study analysis of drug response prediction in cancer cell lines
To enable personalized cancer treatment, machine learning models have been developed
to predict drug response as a function of tumor and drug features. However, most algorithm …
to predict drug response as a function of tumor and drug features. However, most algorithm …
Distance-based support vector machine to predict DNA N6-methyladenine modification
Background: DNA N6-methyladenine plays an important role in the restriction-modification
system to isolate invasion from adventive DNA. The shortcomings of the high time …
system to isolate invasion from adventive DNA. The shortcomings of the high time …
Potent antibiotic design via guided search from antibacterial activity evaluations
L Chen, L Yu, L Gao - Bioinformatics, 2023 - academic.oup.com
Motivation The emergence of drug-resistant bacteria makes the discovery of new antibiotics
an urgent issue, but finding new molecules with the desired antibacterial activity is an …
an urgent issue, but finding new molecules with the desired antibacterial activity is an …
RA-UNet: A hybrid deep attention-aware network to extract liver and tumor in CT scans
Automatic extraction of liver and tumor from CT volumes is a challenging task due to their
heterogeneous and diffusive shapes. Recently, 2D deep convolutional neural networks …
heterogeneous and diffusive shapes. Recently, 2D deep convolutional neural networks …
DRESIS: the first comprehensive landscape of drug resistance information
X Sun, Y Zhang, H Li, Y Zhou, S Shi… - Nucleic acids …, 2023 - academic.oup.com
Widespread drug resistance has become the key issue in global healthcare. Extensive
efforts have been made to reveal not only diverse diseases experiencing drug resistance …
efforts have been made to reveal not only diverse diseases experiencing drug resistance …
A first computational frame for recognizing heparin-binding protein
W Zhu, SS Yuan, J Li, CB Huang, H Lin, B Liao - Diagnostics, 2023 - mdpi.com
Heparin-binding protein (HBP) is a cationic antibacterial protein derived from multinuclear
neutrophils and an important biomarker of infectious diseases. The correct identification of …
neutrophils and an important biomarker of infectious diseases. The correct identification of …
Representation of features as images with neighborhood dependencies for compatibility with convolutional neural networks
Abstract Deep learning with Convolutional Neural Networks has shown great promise in
image-based classification and enhancement but is often unsuitable for predictive modeling …
image-based classification and enhancement but is often unsuitable for predictive modeling …
DTI-CDF: a cascade deep forest model towards the prediction of drug-target interactions based on hybrid features
Drug–target interactions (DTIs) play a crucial role in target-based drug discovery and
development. Computational prediction of DTIs can effectively complement experimental …
development. Computational prediction of DTIs can effectively complement experimental …
GraphCDR: a graph neural network method with contrastive learning for cancer drug response prediction
Predicting the response of a cancer cell line to a therapeutic drug is an important topic in
modern oncology that can help personalized treatment for cancers. Although numerous …
modern oncology that can help personalized treatment for cancers. Although numerous …