Efavirenz metabolism: influence of polymorphic CYP2B6 variants and stereochemistry
PF Wang, A Neiner, ED Kharasch - Drug Metabolism and Disposition, 2019 - ASPET
Efavirenz (more specifically the S-enantiomer) is a cornerstone antiretroviral therapy for
treatment of HIV infection. The major primary metabolite is S-8-hydroxyefavirenz, which does …
treatment of HIV infection. The major primary metabolite is S-8-hydroxyefavirenz, which does …
Common antiretroviral combinations are associated with somatic depressive symptoms in women with HIV
Objective: While modern antiretroviral therapy (ART) is highly effective and safe, depressive
symptoms have been associated with certain ART drugs. We examined the association …
symptoms have been associated with certain ART drugs. We examined the association …
Meta-analysis of the associations of CYP2B6-516G> T polymorphisms with efavirenz-induced central nervous system side effects and virological outcome in HIV …
L Cheng, Y Wang, X Li, W Feng, B Weng… - The …, 2020 - nature.com
Clinical data on the relationships of cytochrome P450 (CYP2) B6 516G> T polymorphisms
with efavirenz-induced central nervous system (CNS) side effects and virological response …
with efavirenz-induced central nervous system (CNS) side effects and virological response …
Influence of CYP2B6 and CYP3A4 polymorphisms on the virologic and immunologic responses of patients treated with efavirenz-containing regimen
Influence of CYP2B6 and CYP3A4 polymorphisms on the virologi... : Pharmacogenetics and
Genomics Influence of CYP2B6 and CYP3A4 polymorphisms on the virologic and immunologic …
Genomics Influence of CYP2B6 and CYP3A4 polymorphisms on the virologic and immunologic …
[HTML][HTML] Investigating the CYP2B6 rs3745274 and rs3211371 Polymorphisms in Methadone-Responder and Non-Responder Addicts in Iran
SSA Afjeh, B Boshehri, S Hamednia… - Iranian Biomedical …, 2021 - ncbi.nlm.nih.gov
Background: Methadone therapy is a major protocol in opioid addiction cases in many
health care systems. Population-based studies have shown that in addicted people, the …
health care systems. Population-based studies have shown that in addicted people, the …
Efavirenz pharmacogenetics and metabolic toxicity in black South Africans
LM Makgai - 2022 - open.uct.ac.za
Background: Efavirenz is associated with hepatotoxicity, dyslipidaemia and dysglycaemia.
We aimed to determine if CYP2B6 composite metaboliser genotypes influence lipids …
We aimed to determine if CYP2B6 composite metaboliser genotypes influence lipids …