Myeloid-specific JAK2 contributes to inflammation and salt sensitivity of blood pressure

M Saleem, LA Aden, AL Mutchler, C Basu… - Circulation …, 2024 - ahajournals.org
BACKGROUND: Salt sensitivity of blood pressure (SSBP), characterized by acute changes
in blood pressure with changes in dietary sodium intake, is an independent risk factor for …

Methods and clinical biomarker discovery for targeted proteomics using Olink technology

H Wang, T Zhao, J Zeng, R Zhang, L Pu… - PROTEOMICS …, 2024 - Wiley Online Library
Purpose This paper is to offer insights for designing research utilizing Olink technology to
identify biomarkers and potential therapeutic targets for disease treatment. Experimental …

Covid-19 in patients with haematological malignancies

H Warda, K Skórka… - Acta Haematologica …, 2024 - journals.viamedica.pl
In most cases, the COVID-19 is characterized by mild clinical course, however, there are
groups of patients at high risk of mortality and morbidity of COVID-19, including the older …

Potential Immune-Inflammatory Proteome Biomarkers for Guiding the Treatment of Patients with Primary Acute Angle-Closure Glaucoma Caused by COVID-19

Q Gong, M Fu, J Wang, S Zhao… - Journal of Proteome …, 2024 - ACS Publications
Primary acute angle-closure glaucoma (PAACG) is a sight-threatening condition that can
lead to blindness. With the increasing incidence of COVID-19, a multitude of people are …

Proteomic profiling identifies biomarkers of COVID-19 severity

NC Harriott, AL Ryan - Heliyon, 2024 - cell.com
SARS-CoV-2 infection remains a major public health concern, particularly for the aged and
those individuals with co-morbidities at risk for developing severe COVID-19. Understanding …

[HTML][HTML] Identification of biomarkers for COVID-19 associated secondary hemophagocytic lymphohistiocytosis

SP Canny, IB Stanaway, SE Holton, M Mitchem… - …, 2024 - pmc.ncbi.nlm.nih.gov
OBJECTIVES: We aimed to define and validate novel biomarkers that could identify
individuals with COVID-19 associated secondary hemophagocytic lymphohistiocytosis …

Morphological changes without histological myocarditis in hearts of COVID-19 deceased patients

A Razaghi, A Szakos, R Al-Shakarji… - Scandinavian …, 2022 - Taylor & Francis
Objective. Patients with underlying heart diseases have a higher risk of dying from Covid-19.
It has also been suggested that Covid-19 affects the heart through myocarditis. Despite the …

Integrated single-cell RNA-seq analysis revealed PTN secreted by fibroblasts acting on itself and macrophages via SDC4 ligand in myocardial hypertrophy

K Sheng, Y Ran, Y Guan, P Tan, R Zhang, S Qian… - bioRxiv, 2024 - biorxiv.org
Background: Hypertrophic cardiomyopathy (HCM) is characterized by massive myocardial
hypertrophy, which is the most frequent cause of sudden death and can lead to heart failure …

Altered ACE2 and interferon landscape in the COVID-19 microenvironment correlate with the anti-PD-1 response in solid tumors

K Subbarayan, A Al-Samadi, H Schäfer, C Massa… - 2024 - researchsquare.com
Abstract Angiotensensin-converting enzyme-2 (ACE2) is a receptor for SARS-CoV-2,
allowing the virus to enter cells. Although tumor patients infected by SARS-CoV-2 often have …

Dendritic cell-specific SMAD3, downstream of JAK2, contributes to inflammation and salt-sensitivity of blood pressure

M Saleem, L Aden, A Mutchler, C Basu, L Ertuglu… - 2023 - researchsquare.com
Salt-sensitivity of blood pressure (SSBP), characterized by acute changes in blood pressure
with changes in dietary sodium intake, is an independent risk factor for cardiovascular …