Insulin and cancer: a tangled web

BP Leitner, S Siebel, ND Akingbesote… - Biochemical …, 2022 - portlandpress.com
For a century, since the pioneering work of Otto Warburg, the interwoven relationship
between metabolism and cancer has been appreciated. More recently, with obesity rates …

The lung, the niche, and the microbe: Exploring the lung microbiome in cancer and immunity

M Huynh, MJ Crane, AM Jamieson - Frontiers in Immunology, 2023 - frontiersin.org
The lung is a complex and unique organ system whose biology is strongly influenced by
environmental exposure, oxygen abundance, connection to extrapulmonary systems via a …

Navigate towards the immunotherapy era: value of immune checkpoint inhibitors in non-small cell lung cancer patients with brain metastases

G Yang, L Xing, X Sun - Frontiers in Immunology, 2022 - frontiersin.org
Brain metastases (BMs) in non-small-cell lung cancer (NSCLC) patients are associated with
significant morbidity and poor prognosis. Immune checkpoint inhibitors (ICIs) have resulted …

Visceral obesity in non-small cell lung cancer

L Nitsche, Y Vedire, E Kannisto, X Wang, RJ Seager… - Cancers, 2022 - mdpi.com
Simple Summary Body mass index may be an inappropriate metric for obesity in lung cancer
as its use obscures the harm that obesity causes, which is noticeable when obesity is …

The association between the amino acid transporter LAT1, tumor immunometabolic and proliferative features and menopausal status in breast cancer

G Ramshankar, R Liu, RJ Perry - Plos one, 2023 - journals.plos.org
L-type Amino Acid Transporter 1 (LAT1) facilitates the uptake of specific essential amino
acids, and due to this quality, it has been correlated to worse patient outcomes in various …

Characterizing cancer metabolism from bulk and single-cell RNA-seq data using METAFlux

Y Huang, V Mohanty, M Dede, K Tsai, M Daher… - Nature …, 2023 - nature.com
Cells often alter metabolic strategies under nutrient-deprived conditions to support their
survival and growth. Characterizing metabolic reprogramming in the tumor …

Unlocking the potential of T‐cell metabolism reprogramming: Advancing single‐cell approaches for precision immunotherapy in tumour immunity

L Huang, H Li, C Zhang, Q Chen, Z Liu… - Clinical and …, 2024 - Wiley Online Library
As single‐cell RNA sequencing enables the detailed clustering of T‐cell subpopulations and
facilitates the analysis of T‐cell metabolic states and metabolite dynamics, it has gained …

The Influence of the Amino Acid Transporter LAT1 on Patient Prognosis and the Relationships between Tumor Immunometabolic and Proliferative Features Depend …

G Ramshankar, R Liu, RJ Perry - medRxiv, 2023 - medrxiv.org
Abstract L-type Amino Acid Transporter 1 (LAT1) facilitates the uptake of specific essential
amino acids, and due to this quality, it has been correlated to worse patient outcomes in …

[PDF][PDF] Predictive value of metabolism and its heterogeneity 18 parameters measured by preoperative F-FDG PET/CT for mediastinal occult lymph node metastasis in …

ZL MM, SZ MM, BQ MM, HC MM, LW MM… - Hellenic Journal of …, 2024 - nuclmed.gr
Objective:: To explore the potential of intratumoral metabolism and its heterogeneous
parameters, as 18 measured by preoperative fluorine-18-fluorodeoxyglucose (F-FDG) …

[PDF][PDF] Investigating Glucose Uptake Prognostic Effects on Pan Cancer TCGA by METAFlux

K Tsai, Y Huang, K Chen - 2022 - openworks.mdanderson.org
Investigating Glucose Uptake Prognostic Effects On Pan Cancer TCGA by METAFLUX Introduction
Methods Results Results Discussion R Page 1 Investigating Glucose Uptake Prognostic …