Gene therapy: Comprehensive overview and therapeutic applications
Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three
facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where …
facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where …
Therapeutic strategies for enhancing angiogenesis in wound healing
The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …
of years. The development of chronic, non-healing wounds is a persistent medical problem …
Delivering CRISPR: a review of the challenges and approaches
CA Lino, JC Harper, JP Carney, JA Timlin - Drug delivery, 2018 - Taylor & Francis
Gene therapy has long held promise to correct a variety of human diseases and defects.
Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the …
Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the …
Recent trends in cancer therapy: A review on the current state of gene delivery
EB Yahya, AM Alqadhi - Life Sciences, 2021 - Elsevier
Cancer treatment has been always considered one of the most critical and vital themes of
clinical issues. Many approaches have been developed, depending on the type and the …
clinical issues. Many approaches have been developed, depending on the type and the …
[HTML][HTML] Recent advances in miRNA delivery systems
I Dasgupta, A Chatterjee - Methods and protocols, 2021 - mdpi.com
MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that
are produced in a tissue and time-specific manner to orchestrate gene expression post …
are produced in a tissue and time-specific manner to orchestrate gene expression post …
[HTML][HTML] Recent advances in CRISPR/Cas9 delivery strategies
BH Yip - Biomolecules, 2020 - mdpi.com
The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system has
revolutionized the field of gene editing. Continuous efforts in developing this technology …
revolutionized the field of gene editing. Continuous efforts in developing this technology …
The war against heart failure: the Lancet lecture
E Braunwald - The Lancet, 2015 - thelancet.com
Heart failure is a global problem with an estimated prevalence of 38 million patients
worldwide, a number that is increasing with the ageing of the population. It is the most …
worldwide, a number that is increasing with the ageing of the population. It is the most …
Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing
R O'Flaherty, A Bergin, E Flampouri, LM Mota… - Biotechnology …, 2020 - Elsevier
The manufacturing of recombinant protein is traditionally undertaken in mammalian cell
culture. Today, speed, cost and safety are the primary considerations for process …
culture. Today, speed, cost and safety are the primary considerations for process …
Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation
Tissue engineering is a promising strategy for the repair of large-scale bone defects, in
which scaffolds and growth factors are two critical issues influencing the efficacy of bone …
which scaffolds and growth factors are two critical issues influencing the efficacy of bone …
Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial
JP Casazza, EM Cale, S Narpala, GV Yamshchikov… - Nature medicine, 2022 - nature.com
Adeno-associated viral vector-mediated transfer of DNA coding for broadly neutralizing anti-
HIV antibodies (bnAbs) offers an alternative to attempting to induce protection by vaccination …
HIV antibodies (bnAbs) offers an alternative to attempting to induce protection by vaccination …