The HIV/AIDS pandemic is an increasing global burden with devastating health-related and
socioeconomic effects. The widespread use of antiretroviral therapy has dramatically …

The continuous replication of HIV-1 in the central nervous system, in particular the brain, and
its potential long-term deleterious effect is the focus of this review. Cognitive deficits are …

Standard methods used to estimate HIV-1 population diversity are often resource intensive
(eg, single genome amplification, clonal amplification and pyrosequencing) and not well …

Combination antiretroviral therapy has significantly reduced morbidity and mortality with HIV
infection. However, HIV-associated neurocognitive disorders persist at a relatively high …

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS)
begins early in systemic infection and continues throughout its untreated course. Despite a …

Approximately 70% of HIV-1 infected patients acquire ocular opportunistic infections and
manifest eye disorders during the course of their illness. The mechanisms by which …

We studied viral evolution in five human leukocyte antigen (HLA)-B* 57 patients recently
infected with HIV-1. Escape mutations in HLA-B* 57-restricted Gag epitopes were present at …

One of the choice criteria for antiretroviral therapy, once the viral load is controlled, is long-
term treatment safety. Safety, despite similarities in each therapeutic class, can differ …

The genetic evolution of HIV-1 in the central nervous system (CNS) is different from that in
peripheral tissues. We analyzed 121 clonal sequences of the V3–V5 regions of the env …

Abstract Purpose of Review The HIV-1 envelope gene (env) has been an intense focus of
investigation in the search for genetic determinants of viral entry and persistence in the …