Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Somatosensory afferents are traditionally classified by soma size, myelination, and their
response specificity to external and internal stimuli. Here, we propose the functional …

Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy,
clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS …

Abstract 'Dysbiosis' of the maternal gut microbiome, in response to challenges such as
infection, altered diet and stress during pregnancy, has been increasingly associated with …

Fibromyalgia (FM) is an idiopathic disorder characterized by generalized pain and
associated symptoms such as depression and anxiety. Cannabis sativa shows different …

Ongoing pain is driven by the activation and modulation of pain-sensing neurons, affecting
physiology, motor function, and motivation to engage in certain behaviors. The complexity of …

Pain decreases the activity of many ventral tegmental area (VTA) dopamine (DA) neurons,
yet the underlying neural circuitry connecting nociception and the DA system is not …

Artificial intelligence (AI) is often used to describe the automation of complex tasks that we
would attribute intelligence to. Machine learning (ML) is commonly understood as a set of …

Microneedle arrays show many advantages in drug delivery applications due to their
convenience and reduced risk of infection. Compared to other microscale manufacturing …

Humans detect skin temperature changes that are perceived as warm or cool. Like humans,
mice report forepaw skin warming with perceptual thresholds of less than 1° C and do not …