Real-time sequence determination

S Hardin, X Gao, J Briggs, R Willson… - US Patent App. 09 …, 2003 - Google Patents
(57) ABSTRACT A sequencing methodology is disclosed that allows a single DNA or RNA
molecule or portion thereof to be sequenced directly and in Substantially real time. The …

Method for analyzing dynamic detectable events at the single molecule level

A Volkov, CM Colbert, I Pan, A Kraltcheva… - US Patent …, 2010 - Google Patents
Allstetete-beleraerédySheilaia (66ptie? is disclosed, where the method includesa ection,
calibration, can didate selection, and analysis of data streams associated with …

Apparatus and method for detection and discrimination molecular object

HC Chen, MC Li, CS Chu, YT Li, CF Chiou - US Patent 9,778,188, 2017 - Google Patents
6, 210, 973 B1 6, 232, 075 B1 6, 255, 083 B1 6, 306, 607 B2 6, 344, 653 B1 6, 362, 002 B1
6, 374, 019 B1 6, 413, 792 B1 6, 618, 536 B1 6, 762, 048 B2 6, 917, 726 B2 6, 946, 249 B2 …

Conjugates of biomolecules to nanoparticles

T Nikiforov, D Mazur, X Peng, TL Lincecum… - US Patent …, 2013 - Google Patents
2011-11-08 Assigned to Life Technologies Corporation reassignment Life Technologies
Corporation ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …

Method and apparatus for moving stage detection of single molecular events

N Battulga, M Reddy, SH Hardin - US Patent App. 11/781,166, 2008 - Google Patents
An apparatus and method based on the apparatus is disclosed for detecting and monitoring
chemical and/or bio-chemical reactions or interactions at the single molecule level, where …

Single-molecule detection system and methods

CF Chiou, YC Pu, CC Pan, CT Shih, MC Li… - US Patent …, 2016 - Google Patents
Embodiments encompass a single-molecule detection sys tem and methods of using the
detection system to detect an object. Further, embodiments encompass a detection system …

Methods for preparing modified biomolecules, modified biomolecules and methods for using same

H Wang, N Deluge, K Kincaid… - US Patent App. 12 …, 2009 - Google Patents
(57) ABSTRACT A novel and efficient single pot synthetic schemes are dis closed for
preparing modified nucleotides, nucleotide ana logs, nucleotide polyphosphates, and …

Methods for sequence determination

S Hardin, X Gao, J Briggs, R Willson… - US Patent App. 11 …, 2007 - Google Patents
(57) ABSTRACT A sequencing methodology is disclosed that allows a single DNA or RNA
molecule or portion thereof to be sequenced directly and in substantially real time. The …

Methods for sequence determination using depolymerizing agent

S Hardin, X Gao, J Briggs, R Willson… - US Patent App. 11 …, 2007 - Google Patents
ABSTRACT A sequencing methodology is disclosed that allows a single DNA or RNA
molecule or portion thereof to be sequenced directly and in substantially real time. The …

Mutant polymerases

S Hardin, X Gao, J Briggs, R Willson… - US Patent App. 11 …, 2007 - Google Patents
(57) ABSTRACT A sequencing methodology is disclosed that allows a single DNA or RNA
molecule or portion thereof to be sequenced directly and in substantially real time. The …