Mechanisms and therapeutic relevance of neuro-immune communication

SS Chavan, VA Pavlov, KJ Tracey - Immunity, 2017 - cell.com
Active research at the frontiers of immunology and neuroscience has identified multiple
points of interaction and communication between the immune system and the nervous …

Molecular and functional neuroscience in immunity

VA Pavlov, SS Chavan, KJ Tracey - Annual review of …, 2018 - annualreviews.org
The nervous system regulates immunity and inflammation. The molecular detection of
pathogen fragments, cytokines, and other immune molecules by sensory neurons generates …

Neural regulation of immunity: molecular mechanisms and clinical translation

VA Pavlov, KJ Tracey - Nature neuroscience, 2017 - nature.com
Studies bridging neuroscience and immunology have identified neural pathways that
regulate immunity and inflammation. Recent research using methodological advances in …

[HTML][HTML] Molecular mechanisms of neuroinflammation in ME/CFS and long COVID to sustain disease and promote relapses

W Tate, M Walker, K Peppercorn… - Frontiers in …, 2022 - frontiersin.org
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease now well-
documented as having arisen commonly from a viral infection, but also from other external …

Connection between systemic inflammation and neuroinflammation underlies neuroprotective mechanism of several phytochemicals in neurodegenerative diseases

J Wang, Y Song, Z Chen… - Oxidative medicine and …, 2018 - Wiley Online Library
Oxidative damage, mitochondrial dysfunction, and neuroinflammation are strongly
implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's …

Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats

S Munshi, MK Loh, N Ferrara, MR DeJoseph… - Brain, behavior, and …, 2020 - Elsevier
A link exists between immune function and psychiatric conditions, particularly depressive
and anxiety disorders. Psychological stress is a powerful trigger for these disorders and …

Current status and challenges associated with CNS-targeted gene delivery across the BBB

S Kimura, H Harashima - Pharmaceutics, 2020 - mdpi.com
The era of the aging society has arrived, and this is accompanied by an increase in the
absolute numbers of patients with neurological disorders, such as Alzheimer's disease (AD) …

A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

Y Arima, D Kamimura, T Atsumi, M Harada… - Elife, 2015 - elifesciences.org
Although pain is a common symptom of various diseases and disorders, its contribution to
disease pathogenesis is not well understood. Here we show using murine experimental …

Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

Y Arima, T Ohki, N Nishikawa, K Higuchi, M Ota… - Elife, 2017 - elifesciences.org
Impact of stress on diseases including gastrointestinal failure is well-known, but molecular
mechanism is not understood. Here we show underlying molecular mechanism using EAE …

Interleukin-6 in Traumatic Brain Injury: A Janus-Faced Player in Damage and Repair

P Ciryam, V Gerzanich, JM Simard - Journal of Neurotrauma, 2023 - liebertpub.com
Traumatic brain injury (TBI) is a common and often devastating illness, with wide-ranging
public health implications. In addition to the primary injury, victims of TBI are at risk for …