Targeting epigenetics: A novel promise for Alzheimer's disease treatment

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Insights into role of microRNA in Alzheimer's disease: from contemporary research to bedside perspective

M Bandakinda, A Mishra - International Journal of Biological …, 2023 - Elsevier
One of the most prevalent neurodegenerative disorders is Alzheimer's disease (AD). Despite
the pervasiveness of AD being considerable, the rates of both diagnosis and therapy are …

Molecular mechanisms and therapeutic strategies for levodopa-induced dyskinesia in Parkinson's disease: a perspective through preclinical and clinical evidence

R Bandopadhyay, N Mishra, R Rana, G Kaur… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is the second leading neurodegenerative disease that is
characterized by severe locomotor abnormalities. Levodopa (L-DOPA) treatment has been …

Neuroepigenetics of ageing and neurodegeneration-associated dementia: an updated review

FA Mir, A Amanullah, BP Jain, Z Hyderi… - Ageing Research …, 2023 - Elsevier
Gene expression is tremendously altered in the brain during memory acquisition, recall, and
forgetfulness. However, non-genetic factors, including environmental elements, epigenetic …

The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

BG Dogaru, C Munteanu - International Journal of Molecular Sciences, 2023 - mdpi.com
This review explores the emerging role of hydrogen sulfide (H2S) in modulating epigenetic
mechanisms involved in neurodegenerative diseases. Accumulating evidence has begun to …

Dissecting the relationship between neuropsychiatric and neurodegenerative disorders

R Gupta, D Advani, D Yadav, RK Ambasta… - Molecular …, 2023 - Springer
Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …

Epidrugs in the therapy of central nervous system disorders: a way to drive on?

MG Gladkova, E Leidmaa, EA Anderzhanova - Cells, 2023 - mdpi.com
The polygenic nature of neurological and psychiatric syndromes and the significant impact
of environmental factors on the underlying developmental, homeostatic, and neuroplastic …

Epigenome editing for targeted DNA (de) methylation: a new perspective in modulating gene expression

K Seem, S Kaur, S Kumar… - Critical Reviews in …, 2024 - Taylor & Francis
Traditionally, it has been believed that inheritance is driven as phenotypic variations
resulting from changes in DNA sequence. However, this paradigm has been challenged and …

A multi-trait association analysis of brain disorders and platelet traits identifies novel susceptibility loci for major depression, Alzheimer's and Parkinson's disease

A Tirozzi, MS Quiccione, C Cerletti, MB Donati… - Cells, 2023 - mdpi.com
Among candidate neurodegenerative/neuropsychiatric risk-predictive biomarkers, platelet
count, mean platelet volume and platelet distribution width have been associated with the …

[HTML][HTML] The role of DNA methylation in progression of neurological disorders and neurodegenerative diseases as well as the prospect of using DNA methylation …

Y Rasmi, A Shokati, A Hassan, SGG Aziz… - IBRO Neuroscience …, 2023 - Elsevier
Genome-wide studies related to neurological disorders and neurodegenerative diseases
have pointed to the role of epigenetic changes such as DNA methylation, histone …