The potential effectiveness of cell therapies is dependent upon homing of transplanted cells
to relevant target organs. In this study we firstly characterise the range of methods employed …

Dendritic cells (DCs) are the most potent APCs, with the ability to orchestrate a repertoire of
immune responses. DCs play a pivotal role in the initiation, programming and regulation of …

Dendritic cells (DC) are professional APCs that regulate innate and adaptive immunity. The
role of fatty-acid synthesis in DC development and function is uncertain. We found that …

Biodegradable nanoparticles have been employed for vaccine delivery, frequently admixed
with adjuvants. Surprisingly, there is little information on their modulation of immune …

AIM: To evaluate the safety and clinical efficacy of a new immunotherapy using both α-Gal
epitope-pulsed dendritic cells (DCs) and cytokine-induced killer cells. METHODS: Freshly …

The antitumour activity of the dendritic cell (DC)-based cellular vaccines is greatly reduced
in hostile tumour microenvironment. Therefore, there are many attempts to eliminate or …

Although mass vaccination of the entire population of an endemic area would be the most
cost-effective tool to diminish Leishmania burden, an effective vaccine is not yet …

Objectives The importance of β2-glycoprotein I (β2GPI)-specific CD4+ T cells in the
development of pathogenic processes in patients with antiphospholipid syndrome (APS) …

A hostile tumor microenvironment, characterized by an abundance of T regulatory cells and
myeloid-derived suppressor cells (MDSCs), considerably limits the efficacy of dendritic cell …

Chemotherapy with low‑molecular weight compounds, despite elimination of cancer cells,
entails adverse effects. To overcome this disadvantage, innovative drug delivery systems …