Marfan syndrome (MFS) is an autosomal-dominant disorder of connective tissue caused by
mutations in the fibrillin-1 (FBN1) gene. Mortality is often due to aortic dissection and rupture …

The involvement of highly reactive oxygen-derived free radicals (ROS) in the genesis and
progression of various cardiovascular diseases, including arrhythmias, aortic dilatation …

People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p. Arg177Gln)
develop thoracic aortic aneurysms and dissections (TAAD) as young adults. Here we report …

Sustained biomaterial thromboresistance has long been a goal and challenge in blood-
contacting device design. Endothelialization is one of the most successful strategies to …

In a mouse model of Marfan syndrome, conventional Verhoeff-Van Gieson staining displays
severe fragmentation, disorganization and loss of the aortic elastic fiber integrity. However …

OBJECTIVE: Losartan potassium (INN losartan), an antihypertensive drug, has been shown
to prevent thoracic aortic aneurysm in Marfan syndrome through the inhibition of …

Congenital heart disease is the most common birth defect in humans. Identifying factors that
are critical to embryonic heart development could further our understanding of the disease …

Cardiovascular disease (CVD) is closely related to chronic kidney disease (CKD), and
patients with CKD have a high risk of CVD-related mortality. Traditional CVD risk factors …

Abstract In individuals with Marfan Syndrome (MFS), fibrillin-1 gene (FBN1) mutations can
lead to vascular wall weakening and dysfunction. The experimental mouse model of MFS …

Fibrillin-1 is the major structural component of the 10 nm-diameter microfibrils that confer key
physical and mechanical properties to virtually every tissue, alone and together with elastin …