Fibrillin‐1, the major component of extracellular microfibrils that associate with insoluble
elastin in elastic fibres, is mainly synthesized during development and postnatal growth and …

Objective: The probability of aortic complications in patients with bicuspid aortic valve is
higher in association with aortic regurgitation (AR) compared with aortic stenosis (AS) or …

Background: Mild intrinsic cardiomyopathy in patients with Marfan syndrome (MFS) has
consistently been evidenced by independent research groups. So far, little is known about …

Marfan syndrome (MFS) is a hereditary disorder of the connective tissue that causes life-
threatening aortic aneurysm, which initiates at the aortic root and can progress into the …

Marfan syndrome (MFS) patients are at risk for cardiovascular disease. In particular, for
aortic aneurysm formation, which ultimately can result in a life-threatening aortic dissection …

Marfan syndrome (MFS) is an autosomal dominant disease of the connective tissue due to
mutations in the fibrillin-1 gene (FBN1). This study aimed at characterizing microelastic …

Marfan syndrome (MFS) is a rare connective tissue disorder caused by mutations in FBN1.
Patients with MFS notably suffer from aortic aneurysm and dissection. Despite considerable …

The objective of the present study was to 1) analyze the ascending aortic proteome within a
mouse model of Marfan syndrome (MFS; Fbn1 C1041G/+) at early and late stages of …

Leukotriene-C 4 synthase (LTC 4 S) generates LTC 4 from arachidonic acid metabolism.
LTC 4 is a proinflammatory factor that acts on plasma membrane cysteinyl leukotriene …

Background and purpose: During development of thoracic aortic aneurysms in a mouse
model of Marfan syndrome, upregulation of matrix metalloproteinase (MMP)‐2 and‐9 was …