Microfibrils are macromolecular complexes associated with elastin to form elastic fibers that
endow extensible tissues, such as arteries, lungs, and skin, with elasticity property. Fibrillin …

Background and purpose: Marfan syndrome, a connective tissue disorder caused by
mutations in FBN1 encoding fibrillin‐1, results in life‐threatening complications in the aorta …

Aortic and visceral aneurysms affect large arterial vessels, including the thoracic and
abdominal aorta, as well as visceral arterial branches, such as the splenic, hepatic, and …

Background Aortic dilation, stiffening, and dissection are common and potentially lethal
complications of Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS), which involve …

Highlights•No medical intervention can completely arrest aneurysmal growth.•Drugs with
immediate translational potential in Marfan syndrome include resveratrol, doxycycline …

Aortic aneurysm is the most life-threatening complication in Marfan syndrome (MFS)
patients. Doxycycline, a nonselective matrix metalloproteinases inhibitor, was reported to …

Marfan syndrome is an autosomal dominantly inherited disorder of connective tissue with
prominent skeletal, ocular, and cardiovascular manifestations. Aortic aneurysm and …

It is well-established that variations of a CGG repeat expansion in the gene FMR1, which
encodes the fragile-X mental retardation protein (FMRP), cause the neurocognitive disorder …

Marfan syndrome (MFS) is a connective tissue disorder that results in aortic root widening
and aneurysm if unmanaged. We have previously reported doxycycline, a nonselective …

Marfan syndrome (MFS) is associated with progressive aortic dilatation, endothelial
dysfunction, and oxidative stress that contribute to the early acute dissection of the vessel …