Background and purpose: Thoracic aortic dissection is a life‐threatening complication of
Marfan syndrome, a connective tissue disorder caused by mutations in the gene encoding …

Marfan syndrome (MFS) is associated with progressive aortic dilatation and endothelial
dysfunction that lead to early acute dissection and rupture of the aorta and sudden death …

Marfan syndrome (MFS) is a connective tissue disorder that is often associated with the
fibrillin-1 (Fbn1) gene mutation and characterized by cardiovascular alterations …

Bioavailability of nitric oxide (NO) is mostly studied in isolated blood vessels. We
investigated changes in basal and receptor-stimulated endothelial NO synthase (eNOS) …

Imidazoline receptors (IR) are classified into three receptor subtypes (I1R, I2R, and I3R) and
previous studies showed that regulation of I2R signaling has neuroprotective potential. In …

Marfan syndrome (MFS) is a connective tissue disorder with autosomal dominant
inheritance. Advances in medicine and surgery have increased the average lifespan of …

Marfan syndrome (MFS) is a rare connective tissue disorder caused by mutations in FBN1.
Patients with MFS notably suffer from aortic aneurysm and dissection. Despite considerable …

Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1
gene, which encodes fibrillin-1, a protein essential for the formation and stabilization of …

Background: Marfan Syndrome (MFS) has been associated with increased aortic stiffness
and left ventricular dysfunction. The latter may be due to the underlying genotype and/or …

Loeys‐Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder, caused
by heterozygous mutations in TGFBR1 or TGFBR2 and characterized by vascular …