Thoracic aortic aneurysm (TAA) has a prevalence of 0.16–0.34% and an incidence of 7.6
per 100,000 person-years, accounting for 1–2% of all deaths in Western countries …

Marfan syndrome (MFS) is associated with progressive aortic dilatation and endothelial
dysfunction that lead to early acute dissection and rupture of the aorta and sudden death …

Background and purpose: Thoracic aortic dissection is a life‐threatening complication of
Marfan syndrome, a connective tissue disorder caused by mutations in the gene encoding …

Bioavailability of nitric oxide (NO) is mostly studied in isolated blood vessels. We
investigated changes in basal and receptor-stimulated endothelial NO synthase (eNOS) …

Marfan syndrome (MFS) is a connective tissue disorder with autosomal dominant
inheritance. Advances in medicine and surgery have increased the average lifespan of …

There are no therapeutics that directly enhance chronic endothelial nitric oxide (NO)
release, which is typically associated with vascular homeostasis. In contrast, angiotensin II …

Thoracic aortic disease (TAD) is often silent until a life-threatening complication occurs.
However, genetic information can inform both identification and treatment at an early stage …

Objective The present study attempts to compare the immunohistochemistry (IHC) of von
Willebrand factor (vWf), endothelial cadherin, Caveolin and endothelial Nitric Oxide …

Loeys‐Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder, caused
by heterozygous mutations in TGFBR1 or TGFBR2 and characterized by vascular …

Marfan syndrome (MFS) is a connective tissue disorder that is often associated with the
fibrillin-1 (Fbn1) gene mutation and characterized by cardiovascular alterations …