Marfan syndrome (MFS) is a connective tissue disorder causing aortic aneurysm formation.
Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available …

Background: Losartan is under evaluation for managing Marfan patients with aortic root
dilatation. Cytochrome P450 (CYP) enzymes convert losartan to E3174 active metabolite …

Marfan syndrome (MS) is an autosomal dominant disorder of connective tissue that is
caused by mutations in the fibrillin-1 (FBN-1) gene that cause degeneration of the artery. It is …

Background/Aims: Vascular smooth muscle in Marfan syndrome, a connective tissue
disorder caused by mutations in FBN1 encoding fibrillin-1, is associated with decreased …

Marfan Syndrome (MFS) is a connective tissue disorder due to mutations in fibrillin-1 (Fbn1),
where a Fbn1 missense mutation (Fbn1C1039G/+) can result in systemic increases in the …

Angiotensin-II and oxidative stress are involved in the genesis of aortic aneurysms, a
phenomenon exacerbated by endothelial nitric oxide synthase (eNOS) deletion or …

The Sinha laboratory has developed protocols for differentiating human pluripotent stem
cells (hPSCs) into vascular smooth muscle cells along developmental lineage-specific …

In individuals with Marfan Syndrome (MFS), fibrillin-1 gene (Fbn1) mutations can lead to
vascular wall weakening and dysfunction. The experimental mouse model of MFS …

Marfan Syndrome (MFS) is a disorder of connective tissues due to mutations in the fibrillin-1
(Fbn1) gene. It has been shown that a missense mutation in the Fbn1 gene (Fbn1C1039G/+) …

Traumatic brain injury (TBI) can chronically increase transforming growth factor-β (TGF-β), a
cytokine implicated in cerebrovascular dysfunction underlying blood-brain barrier (BBB) …