No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice
S Hibender, S Li, AV Postma, ME Hoogeland… - Vascular …, 2022 - vb.bioscientifica.com
Marfan syndrome (MFS) is a connective tissue disorder causing aortic aneurysm formation.
Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available …
Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available …
Pharmacogenetic approach to losartan in Marfan patients: a starting point to improve dosing regimen?
Background: Losartan is under evaluation for managing Marfan patients with aortic root
dilatation. Cytochrome P450 (CYP) enzymes convert losartan to E3174 active metabolite …
dilatation. Cytochrome P450 (CYP) enzymes convert losartan to E3174 active metabolite …
Preliminary analysis of the association of TRPV1 to the formation of Marfan syndrome aneurysms
ME Soto, E Soria Castro, V Guarner Lans… - 2019 - digitum.um.es
Marfan syndrome (MS) is an autosomal dominant disorder of connective tissue that is
caused by mutations in the fibrillin-1 (FBN-1) gene that cause degeneration of the artery. It is …
caused by mutations in the fibrillin-1 (FBN-1) gene that cause degeneration of the artery. It is …
Marfan syndrome decreases Ca2+ wave frequency and vasoconstriction in murine mesenteric resistance arteries without changing underlying mechanisms
HT Syyong, AWY Chung, C Van Breemen - Journal of vascular research, 2011 - karger.com
Background/Aims: Vascular smooth muscle in Marfan syndrome, a connective tissue
disorder caused by mutations in FBN1 encoding fibrillin-1, is associated with decreased …
disorder caused by mutations in FBN1 encoding fibrillin-1, is associated with decreased …
Cerebral Microvascular Density, Permeability of the Blood-Brain Barrier, and Neuroinflammatory Responses Indicate Early Aging Characteristics in a Marfan …
T Curry-Koski, L Curtin, M Esfandiarei, TC Thomas - bioRxiv, 2024 - biorxiv.org
Marfan Syndrome (MFS) is a connective tissue disorder due to mutations in fibrillin-1 (Fbn1),
where a Fbn1 missense mutation (Fbn1C1039G/+) can result in systemic increases in the …
where a Fbn1 missense mutation (Fbn1C1039G/+) can result in systemic increases in the …
Vascular dysfunctions in the isolated aorta of double-transgenic hypertensive mice developing aortic aneurysm
L Waeckel, C Badier-Commander, T Damery… - … -European Journal of …, 2015 - Springer
Angiotensin-II and oxidative stress are involved in the genesis of aortic aneurysms, a
phenomenon exacerbated by endothelial nitric oxide synthase (eNOS) deletion or …
phenomenon exacerbated by endothelial nitric oxide synthase (eNOS) deletion or …
Differentiation and quality control of smooth muscle cells from human pluripotent stem cells via the neural crest lineage
The Sinha laboratory has developed protocols for differentiating human pluripotent stem
cells (hPSCs) into vascular smooth muscle cells along developmental lineage-specific …
cells (hPSCs) into vascular smooth muscle cells along developmental lineage-specific …
[PDF][PDF] PMC10924961.
T Curry, ME Barrameda, TC Thomas… - … BRAIN INJURY IN …, 2024 - repository.arizona.edu
In individuals with Marfan Syndrome (MFS), fibrillin-1 gene (Fbn1) mutations can lead to
vascular wall weakening and dysfunction. The experimental mouse model of MFS …
vascular wall weakening and dysfunction. The experimental mouse model of MFS …
[PDF][PDF] Permeability of the Blood-Brain Barrier, Neuroinflammatory Responses, Altered Glutamate Neurotransmission, and Neurobehavioral Alterations Indicate Early …
TC Thomas, M Esfandiarei - FIBRILLIN-1 MUTATION …, 2024 - repository.arizona.edu
Marfan Syndrome (MFS) is a disorder of connective tissues due to mutations in the fibrillin-1
(Fbn1) gene. It has been shown that a missense mutation in the Fbn1 gene (Fbn1C1039G/+) …
(Fbn1) gene. It has been shown that a missense mutation in the Fbn1 gene (Fbn1C1039G/+) …
[PDF][PDF] Permeability of the Blood-Brain Barrier, Neuroinflammatory Responses, Glutamate Neurotransmission, and Neurobehavioral Alterations After Acute Mild …
TC Thomas, M Esfandiarei - FIBRILLIN-1 MUTATION …, 2024 - repository.arizona.edu
Traumatic brain injury (TBI) can chronically increase transforming growth factor-β (TGF-β), a
cytokine implicated in cerebrovascular dysfunction underlying blood-brain barrier (BBB) …
cytokine implicated in cerebrovascular dysfunction underlying blood-brain barrier (BBB) …