Marfan syndrome (MFS) is a genetic disorder that affects multiple organs. Mortality imposed
by aortic aneurysm and dissections represent the most serious clinical manifestation of MFS …

Marfan syndrome (MFS) is a genetic disorder that frequently leads to aortic root dissection
and aneurysm. Despite promising preclinical and pilot clinical data, a recent large-scale …

Thoracic aortic disease affects people of all ages and the majority of those aged< 60 years
have an underlying genetic cause. There is presently no effective medical therapy for …

Rationale: Aortic aneurysm and dissection (AAD) are major diseases of the adult aorta
caused by progressive medial degeneration of the aortic wall. Although the overproduction …

Regular low-impact physical activity is generally allowed in patients with Marfan syndrome,
a connective tissue disorder caused by heterozygous mutations in the fibrillin-1 gene …

We have described that the progression of thoracic aortic aneurysm in Marfan syndrome is
accompanied with aortic vascular dysfunction. In the present study, we hypothesized that the …

Recent studies have shown that NO is a central mediator in diseases associated with
thoracic aortic aneurysm, such as Marfan syndrome. The progressive dilation of the aorta in …

Background Increasing evidence indicates that redox stress participates in MFS aortopathy,
though its mechanistic contribution is little known. We reported elevated reactive oxygen …

Objective—Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in
the fibrillin-1 gene. Patients with MFS are at risk of aortic aneurysm formation and dissection …

The emerging role of endothelial cells in the pathogenesis of thoracic aortic aneurysm and
dissection Page 1 European Heart Journal (2023) 44, 1262–1264 https://doi.org/10.1093/eurheartj/ehac771 …