Triglycerides, phospholipids, and cholesterol are prominent lipid types that serve diverse
biological functions. These lipids act as vital structural components of cell membranes …

Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …

T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer.
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …

Adoptive T‐cell transfer (ACT) therapies, including of tumor infiltrating lymphocytes (TILs)
and T cells gene‐modified to express either a T cell receptor (TCR) or a chimeric antigen …

Mutation burden, hypoxia, and immunoediting contribute to altered metabolic profiles in
tumor cells, resulting in a tumor microenvironment (TME) characterized by accumulation of …

Tumors employ diverse strategies for immune evasion. Unraveling the mechanisms by
which tumors suppress anti-tumor immunity facilitates the development of immunotherapies …

T cell differentiation is a highly regulated, multi-step process necessary for the progressive
establishment of effector functions, immunological memory, and long-term control of …

Natural Killer (NK) cells are a top contender in the development of adoptive cell therapies for
cancer due to their diverse antitumor functions and ability to restrict their activation against …

Objective: The metabolism of cholesterol has been found to be closely related to the
proliferation, invasion, and metastasis of tumors. The purpose of this study was to investigate …

Evaluating the response to immune checkpoint inhibitors (ICIs) remains an unmet challenge
in triple-negative breast cancer (TNBC). The requirement for cholesterol in the activation and …