Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …

Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Evidence is emerging that several diseases and behavioral pathologies result from defects
in gene function. The best-studied example is cancer, but other diseases such as …

Among many anticancer drugs collectively named “targeted or molecular therapies”
epigenetic drugs are clearly promising. Differently from other agents targeting a single gene …

Although genetics determines endocrine phenotypes, it cannot fully explain the great
variability and reversibility of the system in response to environmental changes. Evidence …

In addition to the genetic alterations, observed in cancer cells, are mitotically heritable
changes in gene expression not encoded by the DNA sequences, which are referred to as …

Hepatotoxicity is among the most frequent reasons for drug withdrawal from the market.
Therefore, there is an urgent need for reliable predictive in vitro tests, which unfailingly …

Background: Cancer cells use several mechanisms to resist the cytotoxic effects of drugs,
resulting in tumor progression and invasion. One such mechanism capitalizes on the body's …

Environmental exposures to hazardous chemicals are associated with a variety of human
diseases and disorders, including cancers. Phase I metabolic activation and detoxification …