[HTML][HTML] Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease

S Yeyeodu, D Hanafi, K Webb, NA Laurie… - Frontiers in …, 2024 - frontiersin.org
Both cancer and cardio-metabolic disease disparities exist among specific populations in
the US. For example, African Americans experience the highest rates of breast and prostate …

sPDGFRβ and neuroinflammation are associated with AD biomarkers and differ by race: The ASCEND Study

B Butts, H Huang, WT Hu, PG Kehoe… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION There remains an urgent need to identify preclinical pathophysiological
mechanisms of Alzheimer's disease (AD) development in high‐risk, racially diverse …

[HTML][HTML] Investigation of trends in gut microbiome associated with colorectal cancer using machine learning

C Yu, Z Zhou, B Liu, D Yao, Y Huang, P Wang… - Frontiers in …, 2023 - frontiersin.org
Background The rapid growth of publications on the gut microbiome and colorectal cancer
(CRC) makes it feasible for text mining and bibliometric analysis. Methods Publications were …

Community-initiated genomics

FLC Jackson - Science, 2023 - science.org
Approximately 200 years ago, a largely enslaved African American workforce was replaced
by paid European workers at Catoctin Iron Furnace in Maryland, USA. The life histories of …

基于蛋白质组学揭示马齿苋通过抑制Caspase 12 蛋白对结直肠炎癌转化小鼠的药效机制研究

陆璐, 苏杭, 季光, 徐汉辰 - 中国中西医结合消化杂志, 2024 - zxyxh.whuhzzs.com
目的探讨马齿苋通过Caspase 12 介导的NOD 信号通路对结直肠炎癌转化小鼠的保护作用机制.
方法将24 只6~ 8 周龄的C57 小鼠, 随机分为正常对照组, 模型组, 马齿苋治疗组 …

Structural enrichment attenuates colitis-associated colon cancer

DJ Sykes, S Solanki, S Chukkapalli, K Williams… - bioRxiv, 2024 - biorxiv.org
Colorectal cancer (CRC) is a major public health concern and disproportionately impacts
racial/ethnic minority populations in the US. Animal models are helpful in examining human …

Mechanistic study of the therapeutic effect of Portulaca oleracea L on colorectal inflammatory cancer transformation in mice by inhibiting Caspase 12 protein based on …

LU Lu, SU Hang, JI Guang… - Chin J Integr Tradit …, 2024 - zxyxhen.whuhzzs.com
Mechanistic study of the therapeutic effect of Portulaca oleracea L on colorectal inflammatory
cancer transformation in mice by inhibiting Caspase 12 protein based on proteomics …

[HTML][HTML] The Role of Fusobacterium Nucleatum in the Gut Microbiome and the Relationship to Promotion of Colorectal Cancer (CRC)

L Kunamneni - jmsgr.tamhsc.edu
Background: Colorectal cancer (CRC) is the second deadliest and third most common
cancer globally. ¹ Although the mortality rate for CRC has decreased over the past two …