Peptides are important components of human nutrition and health, and considered as safe,
nontoxic, and easily absorbed potential drugs. Anti-hypoxia peptides are a kind of peptides …

Myeloid-derived suppressor cells (MDSC) are myeloid cells that suppress the immune
response, a definition that reflects both their origin and their function. As negative regulators …

Hypoxia is a hallmark of various ischemic diseases such as ischemic heart disease,
ischemic limb, ischemic stroke, and solid tumors. Gene therapies for these diseases have …

Pancreatic islet transplantation as a therapeutic option for type 1 diabetes mellitus is gaining
widespread attention because this approach can restore physiological insulin secretion …

Agonists of growth hormone-releasing hormone (GHRH) have been previously reported to
promote growth, function, and engraftment of islet cells following transplantation. Here we …

Islet transplantation remains the only alternative to daily insulin therapy for control of type 1
diabetes (T1D) in humans. To avoid the drawbacks of intrahepatic islet transplantation, we …

We have developed a bioengineered implant (BI) to evaluate strategies to promote graft
survival and function in models of islet transplantation in mice. The BI, sized for implantation …

According to the figures released by the International Diabetes Federation (IDF), there were
more than 4.8 million diabetes-related deaths in 2012 alone, and a total of 371 million …

Type 1 diabetes mellitus is an autoimmune disease that is characterized by the destruction
of the islets of Langerhans cells which produce insulin. The current gold standard treatment …

Diabetes is a complex metabolic disease and islet transplantation is a promising approach
for the treatment of diabetes. Unfortunately, the transplanted islets at the subcutaneous site …