ATP-binding cassette efflux transporters and MDR in cancer
MS Pote, RN Gacche - Drug Discovery Today, 2023 - Elsevier
Highlights•The most common reason for the failure of the cancer treatment is the evolving
drug resistance.•The ABC transporters mainly P-gp, BCRP and MRP1 are responsible for …
drug resistance.•The ABC transporters mainly P-gp, BCRP and MRP1 are responsible for …
[HTML][HTML] Targeting multidrug resistance in cancer by natural chemosensitizers
AR Hamed, NS Abdel-Azim, KA Shams… - Bulletin of the National …, 2019 - Springer
Background Statistics on cancer incidence and mortalities indicate that this disease still has
a fatal outcome for a majority of patients due to non-sufficient treatment. The options …
a fatal outcome for a majority of patients due to non-sufficient treatment. The options …
[HTML][HTML] Role of ABC transporters in cancer chemotherapy
Multidrug resistance (MDR) in cancer cells can significantly attenuate the response to
chemotherapy and increase the likelihood of mortality. The major mechanism involved in …
chemotherapy and increase the likelihood of mortality. The major mechanism involved in …
Development of fourth generation ABC inhibitors from natural products: a novel approach to overcome cancer multidrug resistance
S Karthikeyan… - Anti-Cancer Agents in …, 2015 - ingentaconnect.com
Multidrug resistance (MDR) in cancer caused due to overexpression of ABC drug
transporters is a major problem in modern chemotherapy. Molecular investigations on MDR …
transporters is a major problem in modern chemotherapy. Molecular investigations on MDR …
Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design
With the aim to help drug discovery against dengue virus (DENV), a fragment-based drug
design approach was applied to identify ligands targeting a main component of DENV …
design approach was applied to identify ligands targeting a main component of DENV …
Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein
Breast cancer resistance protein (BCRP/ABCG2) belongs to the ATP binding cassette family
of transport proteins. BCRP has been found to confer multidrug resistance in cancer cells. A …
of transport proteins. BCRP has been found to confer multidrug resistance in cancer cells. A …
Small‐molecule inhibitors of multidrug resistance‐associated protein 1 and related processes: A historic approach and recent advances
Multidrug resistance‐associated protein 1 (MRP1, ABCC1) is an ATP‐binding cassette
(ABC) transport protein. This efflux pump uses the energy of ATP hydrolysis to export …
(ABC) transport protein. This efflux pump uses the energy of ATP hydrolysis to export …
Specific inhibitors of the breast cancer resistance protein (BCRP)
A Pick, W Klinkhammer, M Wiese - ChemMedChem, 2010 - Wiley Online Library
A new class of specific breast cancer resistance protein (BCRP) inhibitors was identified,
showing no inhibition of the ATP binding cassette (ABC) transporters P‐gp and MRP1 …
showing no inhibition of the ATP binding cassette (ABC) transporters P‐gp and MRP1 …
Combined pharmacophore modeling, docking, and 3D QSAR studies of ABCB1 and ABCC1 transporter inhibitors
Quinazolinones, indolo‐and pyrrolopyrimidines with inhibitory effects toward ABCB1 (P‐gp)
and ABCC1 (MRP1) transporters were studied by pharmacophore modeling, docking, and …
and ABCC1 (MRP1) transporters were studied by pharmacophore modeling, docking, and …
Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives
With an aim to generate non-toxic, specific and highly potent multidrug resistance (MDR)
modulators, a novel series of anthranilic acid amide-substituted tariquidar derivatives were …
modulators, a novel series of anthranilic acid amide-substituted tariquidar derivatives were …