Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5–10% of
women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism …

Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of
maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

BACKGROUND Despite significant advances in our understanding of the pathophysiology
of preeclampsia (PE), there are still many unknowns and controversies in the field. Women …

Although neutrophils are known to be fundamental in controlling innate immune responses,
their role in regulating adaptive immunity is just starting to be appreciated. We report that …

Hypoxia is a common and severe stress to an organism's homeostatic mechanisms, and
hypoxia during gestation is associated with significantly increased incidence of maternal …

Extravillous trophoblast remodeling of the uterine spiral arteries is essential for promoting
blood flow to the placenta and fetal development, but little is known about the regulation of …

The proper functioning of the monocyte–macrophage system, an important unit of innate
immunity, ensures the normal course of pregnancy. In this review, we present the current …

Adequate maternal vascular adaptations and blood supply to the uterus and placenta are
crucial for optimal oxygen and nutrient transport to growing fetuses of eutherian mammals …

Normal pregnancy is associated with dramatic increases in uterine blood flow to facilitate the
bidirectional maternal–fetal exchanges of respiratory gases and to provide sole nutrient …