РОЛЬ ПЛАЦЕНТАРНЫХ МАКРОФАГОВ ПРИ ФИЗИОЛОГИЧЕСКОЙ БЕРЕМЕННОСТИ И
ПРЕ Page 1 АКУШЕРСТВО И ГИНЕКОЛОГИЯ № 4 /2022 AKUSHERSTVO I …

Preeclampsia (PE) is a multisystem pregnancy complication that is the leading cause of
maternal and perinatal morbidity and mortality. Today, a large body of data has been …

Abstract Introduction 2-Methoxyestradiol (2-ME), a metabolite of estradiol, has been
identified as an initiator of cytotrophoblast transformation to an invasive phenotype, with low …

VEGFR2 is a central regulator of placental angiogenesis. The study of the VEGFR2
proteome of chorionic villi at term revealed its partners MDMX and PICALM. The oxytocin …

VEGF, oestrogen and its metabolites via interaction with distinct receptors activate the MAPK
pathways, leading to endothelial cell proliferation during pregnancy. VEGF-A interacts with …

Abstract Objective 2-Methoxyestradiol (2ME) deficiency leading to placental insufficiency
has been related to pre-eclampsia (PE). Here we investigate whether 2ME is related to …

Nitric oxide (NO) production is essential to facilitate rises in uterine blood flow (UBF) during
pregnancy. It has been proposed that the metabolites of E2β, 2-hydroxyestradiol (2-OHE2) …

Introduction Estrogen hormones and their metabolites are implicated in the maintenance of
healthy pregnancy and adequate fetal development. Abnormal levels were related to …

Purpose Compared to white women, Black women have increased risk of developing
hypertensive diseases of pregnancy (HDOP) and have a higher incidence of aggressive …

methoxyestradiol (2me2), a metabolite of 17β-estradiol (E2), has been tested in phase II
clinical cancer trials and models of inflammation. Its effects are only partly clarified. We …