Revisiting rodent models: Octodon degus as Alzheimer's disease model?

J Steffen, M Krohn, K Paarmann, C Schwitlick… - Acta neuropathologica …, 2016 - Springer
Alzheimer's disease primarily occurs as sporadic disease and is accompanied with vast
socio-economic problems. The mandatory basic research relies on robust and reliable …

Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

J Zhang, F Gao, Y Ma, T Xue, Y Shen - Iscience, 2021 - cell.com
Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including
rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic …

Revelations about aging and disease from unconventional vertebrate model organisms

Y Zhao, A Seluanov, V Gorbunova - Annual review of genetics, 2021 - annualreviews.org
Aging is a major risk factor for multiple diseases. Understanding the underlying mechanisms
of aging would help to delay and prevent age-associated diseases. Short-lived model …

Accelerating Alzheimer's research through 'natural'animal models

N Braidy, A Poljak, T Jayasena… - Current opinion in …, 2015 - journals.lww.com
Accelerating Alzheimer's research through ‘natural’ animal m... : Current Opinion in Psychiatry
Accelerating Alzheimer's research through ‘natural’ animal models : Current Opinion in …

Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus

LY Du, LYL Chang, AO Ardiles, C Tapia-Rojas… - PLoS one, 2015 - journals.plos.org
New studies show that the retina also undergoes pathological changes during the
development of Alzheimer's disease (AD). While transgenic mouse models used in these …

Diseases in pet degus: a retrospective study in 300 animals

V Jekl, K Hauptman, Z Knotek - Journal of Small Animal …, 2011 - Wiley Online Library
Introduction: Degus are commonly used as laboratory animals; however, over the past few
years, they have become increasingly popular as pets. Objectives: The aim of this article …

Biological basis for amyloidogenesis in Alzheimer's disease

TV Andreeva, WJ Lukiw, EI Rogaev - Biochemistry (Moscow), 2017 - Springer
Certain cellular proteins normally soluble in the living organism under certain conditions
form aggregates with a specific cross-β sheet structure called amyloid. These intraor …

Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer's disease

CA Oliva, M Lira, C Jara, A Catenaccio… - Frontiers in Aging …, 2023 - frontiersin.org
Social interactions have a significant impact on health in humans and animal models. Social
isolation initiates a cascade of stress-related physiological disorders and stands as a …

Age-related brain pathology in Octodon degu: blood vessel, white matter and Alzheimer-like pathology

T van Groen, I Kadish, N Popović, M Popović… - Neurobiology of …, 2011 - Elsevier
Recently it has been shown that over 3-year-old wild-type South American rodents, Octodon
degus, the “common degu” or degu, of their own accord develop Alzheimer's disease …

Mammalian Models in Alzheimer's Research: An Update

H Sharma, KA Chang, J Hulme, SSA An - Cells, 2023 - mdpi.com
A form of dementia distinct from healthy cognitive aging, Alzheimer's disease (AD) is a
complex multi-stage disease that currently afflicts over 50 million people worldwide …