Revisiting rodent models: Octodon degus as Alzheimer's disease model?
J Steffen, M Krohn, K Paarmann, C Schwitlick… - Acta neuropathologica …, 2016 - Springer
Alzheimer's disease primarily occurs as sporadic disease and is accompanied with vast
socio-economic problems. The mandatory basic research relies on robust and reliable …
socio-economic problems. The mandatory basic research relies on robust and reliable …
Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including
rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic …
rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic …
Revelations about aging and disease from unconventional vertebrate model organisms
Aging is a major risk factor for multiple diseases. Understanding the underlying mechanisms
of aging would help to delay and prevent age-associated diseases. Short-lived model …
of aging would help to delay and prevent age-associated diseases. Short-lived model …
Accelerating Alzheimer's research through 'natural'animal models
Accelerating Alzheimer's research through ‘natural’ animal m... : Current Opinion in Psychiatry
Accelerating Alzheimer's research through ‘natural’ animal models : Current Opinion in …
Accelerating Alzheimer's research through ‘natural’ animal models : Current Opinion in …
Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus
New studies show that the retina also undergoes pathological changes during the
development of Alzheimer's disease (AD). While transgenic mouse models used in these …
development of Alzheimer's disease (AD). While transgenic mouse models used in these …
Diseases in pet degus: a retrospective study in 300 animals
V Jekl, K Hauptman, Z Knotek - Journal of Small Animal …, 2011 - Wiley Online Library
Introduction: Degus are commonly used as laboratory animals; however, over the past few
years, they have become increasingly popular as pets. Objectives: The aim of this article …
years, they have become increasingly popular as pets. Objectives: The aim of this article …
Biological basis for amyloidogenesis in Alzheimer's disease
Certain cellular proteins normally soluble in the living organism under certain conditions
form aggregates with a specific cross-β sheet structure called amyloid. These intraor …
form aggregates with a specific cross-β sheet structure called amyloid. These intraor …
Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer's disease
Social interactions have a significant impact on health in humans and animal models. Social
isolation initiates a cascade of stress-related physiological disorders and stands as a …
isolation initiates a cascade of stress-related physiological disorders and stands as a …
Age-related brain pathology in Octodon degu: blood vessel, white matter and Alzheimer-like pathology
T van Groen, I Kadish, N Popović, M Popović… - Neurobiology of …, 2011 - Elsevier
Recently it has been shown that over 3-year-old wild-type South American rodents, Octodon
degus, the “common degu” or degu, of their own accord develop Alzheimer's disease …
degus, the “common degu” or degu, of their own accord develop Alzheimer's disease …
Mammalian Models in Alzheimer's Research: An Update
A form of dementia distinct from healthy cognitive aging, Alzheimer's disease (AD) is a
complex multi-stage disease that currently afflicts over 50 million people worldwide …
complex multi-stage disease that currently afflicts over 50 million people worldwide …