Role of species-specific primary structure differences in Aβ42 assembly and neurotoxicity
R Roychaudhuri, X Zheng, A Lomakin… - ACS chemical …, 2015 - ACS Publications
A variety of species express the amyloid β-protein (Aβ (the term “Aβ” refers both to Aβ40 and
Aβ42, whereas “Aβ40” and “Aβ42” refer to each isoform specifically). Those species …
Aβ42, whereas “Aβ40” and “Aβ42” refer to each isoform specifically). Those species …
Looking for the keys to diurnality downstream from the circadian clock: role of melatonin in a dual‐phasing rodent, Octodon degus
Melatonin is an essential component for circadian system function, whose daily plasma
secretory rhythm is driven by the suprachiasmatic nucleus (SCN), contributing to the …
secretory rhythm is driven by the suprachiasmatic nucleus (SCN), contributing to the …
Long-term behavioral effects of social separation during early life in a social mammal, Octodon degus
R Ukyo, A Shinohara, C Koshimoto, GA Nagura-Kato… - Scientific Reports, 2023 - nature.com
Social separation is thought to induce a strong stress response in social juvenile mammals,
but little is known about how this response might vary throughout the development. The …
but little is known about how this response might vary throughout the development. The …
New insights into the spontaneous human Alzheimer's disease-like model Octodon degus: Unraveling amyloid-β peptide aggregation and age-related amyloid …
P Cisternas, JM Zolezzi, C Lindsay… - Journal of …, 2018 - content.iospress.com
Alzheimer's disease (AD) is the most common cause of dementia worldwide. Despite
advances in our understanding of the molecular milieu driving AD pathophysiology, no …
advances in our understanding of the molecular milieu driving AD pathophysiology, no …
Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus
E Tarragon, D Lopez, C Estrada, A Gonzalez-Cuello… - …, 2014 - Elsevier
Memory loss is one of the key features of cognitive impairment in either aging, Mild
Cognitive Impairment (MCI) or dementia. Pharmacological treatments for memory loss are …
Cognitive Impairment (MCI) or dementia. Pharmacological treatments for memory loss are …
Alzheimer's disease modeling: ups, downs, and perspectives for human induced pluripotent stem cells
U Wojda, J Kuznicki - Journal of Alzheimer's Disease, 2013 - content.iospress.com
Major breakthroughs are required to win the war against the increasing threat of Alzheimer's
disease. Until now, however, despite enormous efforts and funds, effective therapies are …
disease. Until now, however, despite enormous efforts and funds, effective therapies are …
A Multivariate Assessment of Age-Related Cognitive Impairment in Octodon degus
Aging is a progressive functional decline characterized by a gradual deterioration in
physiological function and behavior. The most important age-related change in cognitive …
physiological function and behavior. The most important age-related change in cognitive …
Natural AD-Like neuropathology in Octodon degus: impaired burrowing and neuroinflammation
R MJ Deacon, FJ Altimiras… - Current Alzheimer …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is the most common cause of dementia, affecting more than 36
million people worldwide. Octodon degus, a South American rodent, has been found to …
million people worldwide. Octodon degus, a South American rodent, has been found to …
On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae)
Cognitive ecologist posits that the more efficiently an animal uses information from the biotic
and abiotic environment, the more adaptive are its cognitive abilities. Nevertheless, this …
and abiotic environment, the more adaptive are its cognitive abilities. Nevertheless, this …
Octodon degus: a natural model of multimorbidity for ageing research
L Cuenca-Bermejo, E Pizzichini… - Ageing Research …, 2020 - Elsevier
Integrating the multifactorial processes co-occurring in both physiological and pathological
human conditions still remains one of the main challenges in translational investigation …
human conditions still remains one of the main challenges in translational investigation …