The sigma subunit of procaryotic RNA polymerases is responsible for specific promoter
recognition and transcription initiation. In addition to the major sigma factor, σ70, in …

One major paradigm for RNA‐based regulation in both eukaryotes and prokaryotes is small
regulatory RNAs (sRNAs) that pair with mRNAs, leading to changes in translation and …

Signal transduction pathways that communicate information from the cell envelope to the
cytoplasm of bacteria are crucial to maintain cell envelope homeostasis. In Escherichia coli …

Bacterial transcriptional networks are built on a hierarchy of regulators, on top of which lie
the components of the RNA polymerase (in particular the sigma factors) and the global …

We previously characterized a defective‐folding mutant of maltose‐binding protein of
Escherichia coli, MalE31, which formed periplasmic inclusion bodies. Here, we show that …

Proteolytic cascades often transduce signals between cellular compartments, but the
features of these cascades that permit efficient conversion of a biological signal into a …

Biological systems have evolved complex regulatory mechanisms, even in situations where
much simpler designs seem to be sufficient for generating nominal functionality. Using …

Proteolytic cascades are widely implicated in signaling between cellular compartments. In
Escherichia coli, accumulation of unassembled outer membrane porins (OMPs) in the …

Mucoidy, or overproduction of the exopolysaccharide known as alginate, in Pseudomonas
aeruginosa is a poor prognosticator for lung infections in cystic fibrosis. Mutation of the anti-σ …

Over the past decade, regulatory proteolysis has emerged as a paradigm for
transmembrane signal transduction in all organisms, from bacteria to humans. These …