Epidemiology and etiology of Parkinson's disease: a review of the evidence

K Wirdefeldt, HO Adami, P Cole, D Trichopoulos… - European journal of …, 2011 - Springer
The etiology of Parkinson's disease (PD) is not well understood but likely to involve both
genetic and environmental factors. Incidence and prevalence estimates vary to a large …

Pros and cons for statins use and risk of Parkinson's disease: An updated perspective

HM Al‐kuraishy, AI Al‐Gareeb, A Alexiou… - Pharmacology …, 2023 - Wiley Online Library
Parkinson's disease (PD) is the second most frequent neurodegenerative brain disease
(NBD) after Alzheimer's disease (AD). Statins are the most common lipid‐lowering agents …

Prospective study of statin use and risk of Parkinson disease

X Gao, KC Simon, MA Schwarzschild… - Archives of …, 2012 - jamanetwork.com
Objective To prospectively examine whether use of statins is associated with altered risk of
Parkinson disease (PD). Design, Setting, and Participants A prospective study including 38 …

[PDF][PDF] Epidemiology of Parkinson's disease.

L Tan - Neurology Asia, 2013 - neurology-asia.org
The burden of Parkinson's disease (PD) is likely to increase in the years to come as many
countries, particularly those in Asia, face an ageing population. As such, it has been …

[HTML][HTML] Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease

L Lim, V Jackson-Lewis, LC Wong, GH Shui… - Cell Death & …, 2012 - nature.com
Parkinson's disease (PD) is a neurodegenerative disorder marked by the selective
degeneration of dopaminergic neurons in the nigrostriatal pathway. Several lines of …

Statins and prostate cancer: molecular and clinical aspects

G Papadopoulos, D Delakas, L Nakopoulou… - European Journal of …, 2011 - Elsevier
The field of the potential applications of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)
reductase inhibitors (statins) beyond their unambiguous cardiovascular beneficial effects is …

[HTML][HTML] Atorvastatin improves cognitive, emotional and motor impairments induced by intranasal 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) …

AA Castro, BP Wiemes, FC Matheus, FR Lapa… - Brain research, 2013 - Elsevier
Affective disorders and memory impairments precede the classical motor symptoms seen in
Parkinson's disease (PD) and the currently approved antiparkinsonian agents do not …

Statin use and risk of Parkinson's disease: a meta-analysis of observational studies

K Undela, K Gudala, S Malla, D Bansal - Journal of neurology, 2013 - Springer
Inconsistent results regarding the association between statin use and risk of Parkinson's
disease (PD) have been reported. We therefore examined the association between statin …

[HTML][HTML] Perspective insights of repurposing the pleiotropic efficacy of statins in neurodegenerative disorders: An expository appraisal

A Bhat, H Dalvi, H Jain, N Rangaraj, SB Singh… - Current Research in …, 2021 - Elsevier
Neurodegenerative disorders which affects a larger population pose a great clinical
challenge. These disorders impact the quality of life of an individual by damaging the …

[HTML][HTML] α-Synuclein-Induced Synapse Damage in Cultured Neurons Is Mediated by Cholesterol-Sensitive Activation of Cytoplasmic Phospholipase A2

C Bate, A Williams - Biomolecules, 2015 - mdpi.com
The accumulation of aggregated forms of the α-synuclein (αSN) is associated with the
pathogenesis of Parkinson's disease (PD) and Dementia with Lewy Bodies. The loss of …