Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …

Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …

Abstract Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of
physiological functions such as blood pressure regulation, apoptotic cell clearance and …

Extracellular nucleotides and nucleosides promote a vast range of physiological responses,
via activation of cell surface purinergic receptors. Virtually all tissues and cell types exhibit …

Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called
connexins are transmembrane conduits for the exchange of small molecules and ions …

Pannexins are large-pore ion channels with broad expression in the central nervous system
(CNS). The channels function by releasing large signaling molecules, such ATP and …

Plasma membrane hemichannels composed of connexin (Cx) proteins are essential
components of gap junction channels but accumulating evidence suggests functions of …

The pannexin proteins represent a new gap junction family. However, the cellular functions
of pannexins remain largely unknown. Here, we demonstrate that pannexin 3 (Panx3) …

Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed
throughout the body. Panx1 activation results in the release of nucleotides such as …

Connexins and pannexins are two families of large-pore channel forming proteins that are
capable of passing small signaling molecules. While connexins serve the seminal task of …