Pannexin1 (PANX1) is probably best understood as an ATP release channel involved in
paracrine signaling. Given its ubiquitous expression, PANX1 pathogenic variants would be …

Pannexin (Panx) 1 and Panx3 are integral membrane proteins that share some sequence
homology with the innexin family of invertebrate gap junctions. They are expressed in …

The pannexin (Panx) family of proteins, which is co-expressed with connexins (Cxs) in
vertebrates, was found to be a new GJ-forming protein family related to invertebrate …

Pannexins are a class of chordate channel proteins identified by their homology to insect
gap junction proteins. The pannexin family consists of three members, Panx1, Panx2, and …

The pannexins (Panx1,-2, and-3) are a mammalian family of putative single membrane
channels discovered through homology to invertebrate gap junction-forming proteins, the …

Aims: Pannexins (Panx) form ATP release channels and it has been proposed that they play
an important role in the regulation of vascular tone. However, distribution of Panx across the …

Pannexins are a 3-membered family of proteins that form large pore ion and metabolite
channels in vertebrates. The impact of pannexins on vertebrate biology is intricately tied to …

The ubiquitous pannexin 1 (Panx1) ion-and metabolite-permeable channel mediates the
release of ATP, a potent signalling molecule. In the present study, we provide striking …

Abstract Pannexin-1 (Panx1) expression is raised in several animal seizure models and in
resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that …

Pannexins, large non-gap junction super family exists in vertebrates, play multiple roles in
different cellular functions through their ATP release. Panx1-mediated adenosine 5 …