Connexin (Cx) and pannexin (Panx) proteins form large conductance channels, which
function as regulators of communication between neighbouring cells via gap junctions …

Having shown that Panx1 and Panx3 are expressed in the epidermis, we investigated their
distribution in human skin adnexal structures and skin cancer. Both proteins were found in …

Pannexins belong to a family of ATP-release channels expressed in almost all cell types. An
increasing body of literature on pannexins suggests that these channels play dual and …

Gram-positive bacterial cell wall components including PGN (peptidoglycan) elicit a potent
pro-inflammatory response in diverse cell types, including endothelial cells, by activating …

Death of murine T cells induced by extracellular ATP is mainly triggered by activation of
purinergic P2X7 receptors (P2X7Rs). However, a link between P2X7Rs and pannexin1 …

Osteocytes are considered the primary mechanosensors of bone, but the signaling
pathways they apply in mechanotransduction are still incompletely investigated and …

An exaggerated inflammatory response is the hallmark of a plethora of disorders. ATP is a
central signaling molecule that orchestrates the initiation and resolution of the inflammatory …

Abstract Pannexin 1 (Panx1) is a channel-forming glycoprotein important in paracrine
signaling and cellular development. In this study, we discovered that mice globally lacking …

Epithelial tissues line the lumen of tracts and ducts connecting to the external environment.
They are critical in forming an interface between the internal and external environment and …

HOW ATP AND OTHER NUCLEOTIDES are released from intact cells is a fundamental
question, given the existence of multiple purinergic receptor signaling cascades operative in …