The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

In the last decades, autoimmune diseases have experienced a dramatic increase in Western
countries. The involvement of environmental factors is strongly suspected to explain this rise …

Abstract Type 1 diabetes (T1DM) is an autoimmune disease with aberrant immune
responses to specific β-cell autoantigens, resulting in insulin deficiency. Children and …

Circulating levels of adiponectin (APN) are reduced in obesity and associated comorbidities,
with inflammation playing an important role in downregulating APN production. In contrast to …

Background The incidence of type 1 diabetes (T1D) is increasing globally. One hypothesis is
that increasing childhood obesity rates may explain part of this increase, but, as T1D is rare …

During an inflammatory response, lymphocyte recruitment into tissue must be tightly
controlled because dysregulated trafficking contributes to the pathogenesis of chronic …

Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose
metabolism and insulin resistance. Within the bone, osteoblasts and osteoclasts express the …

Adiponectin, as an indispensable regulator of the immune system, is the most abundant
adipokine and is mainly produced by white adipose tissue. Adiponectin mediates the …

New Findings What is the topic of this review? This review discusses the evidence of the
benefits of exercise training for β‐cell health through improvements in function, proliferation …

OBJECTIVE Sustained excess BMI increases the risk of type 1 diabetes (T1D) in
autoantibody-positive relatives without diabetes of patients. We tested whether elevated BMI …