Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Abstract Purpose This Position Paper aims to review and discuss the available data on
therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill …

Estimating static kidney function accurately and detecting changes in kidney function in a
timely fashion are challenging but critically important tasks. Serum creatinine is the most …

Sepsis is a common consequence of infection, associated with a mortality rate> 25%.
Although community-acquired sepsis is more common, hospital-acquired infection is more …

The rapid emergence and dissemination of antimicrobial-resistant microorganisms in ICUs
worldwide constitute a problem of crisis dimensions. The root causes of this problem are …

Background Early and appropriate antibiotic dosing is associated with improved clinical
outcomes in critically ill patients, yet target attainment remains a challenge. Traditional …

Background Traditionally, renal function in critically ill patients has been assessed to identify
renal dysfunction, and dose adjustment is generally accepted in such a context …

Objectives To describe the achievement of unbound β-lactam antibiotic concentration
targets in a therapeutic drug monitoring (TDM) programme in critically ill patients, and the …

Whilst augmented renal clearance (ARC) is associated with reduced β-lactam plasma
concentrations, its impact on clinical outcomes is unclear. This single-centre prospective …

Infections occur frequently in critically ill patients and their management can be challenging
for various reasons, including delayed diagnosis, difficulties identifying causative …