Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
B Wang, L Wu, J Chen, L Dong, C Chen… - Signal transduction and …, 2021 - nature.com
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
[HTML][HTML] The essential role of exercise in the management of type 2 diabetes
JP Kirwan, J Sacks, S Nieuwoudt - Cleveland Clinic journal of …, 2017 - ncbi.nlm.nih.gov
Exercise is typically one of the first management strategies advised for patients newly
diagnosed with type 2 diabetes. Together with diet and behavior modification, exercise is an …
diagnosed with type 2 diabetes. Together with diet and behavior modification, exercise is an …
[HTML][HTML] mTOR signaling in growth control and disease
M Laplante, DM Sabatini - cell, 2012 - cell.com
The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a
variety of environmental cues to regulate organismal growth and homeostasis. The pathway …
variety of environmental cues to regulate organismal growth and homeostasis. The pathway …
Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications
K Cusi - Gastroenterology, 2012 - Elsevier
As obesity reaches epidemic proportions, nonalcoholic fatty liver disease (NAFLD) is
becoming a frequent cause of patient referral to gastroenterologists. There is a close link …
becoming a frequent cause of patient referral to gastroenterologists. There is a close link …
Diabetes mellitus related bone metabolism and periodontal disease
YY Wu, E Xiao, DT Graves - International journal of oral science, 2015 - nature.com
Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of
populations worldwide. Changed bone metabolism is one of the important long-term …
populations worldwide. Changed bone metabolism is one of the important long-term …
Obesity as an emerging risk factor for iron deficiency
E Aigner, A Feldman, C Datz - Nutrients, 2014 - mdpi.com
Iron homeostasis is affected by obesity and obesity-related insulin resistance in a many-
facetted fashion. On one hand, iron deficiency and anemia are frequent findings in subjects …
facetted fashion. On one hand, iron deficiency and anemia are frequent findings in subjects …
Pre-diabetes, metabolic syndrome, and cardiovascular risk
SM Grundy - Journal of the American College of Cardiology, 2012 - jacc.org
Pre-diabetes represents an elevation of plasma glucose above the normal range but below
that of clinical diabetes. Pre-diabetes can be identified as either impaired fasting glucose …
that of clinical diabetes. Pre-diabetes can be identified as either impaired fasting glucose …
Association between midlife obesity and its metabolic consequences, cerebrovascular disease, and cognitive decline
Context Chronic obesity is associated with several complications, including cognitive
impairment and dementia. However, we have only piecemeal knowledge of the mechanisms …
impairment and dementia. However, we have only piecemeal knowledge of the mechanisms …
[PDF][PDF] Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
R Lomonaco, C Ortiz‐Lopez, B Orsak, A Webb… - …, 2012 - Wiley Online Library
The role of adipose tissue insulin resistance in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) remains unclear. To evaluate this, we measured in 207 patients with …
disease (NAFLD) remains unclear. To evaluate this, we measured in 207 patients with …
Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis
D Vyas, G Laput, AK Vyas - OncoTargets and therapy, 2014 - Taylor & Francis
The lack of therapy and the failure of existing therapy has been a challenge for clinicians in
treating various cancers. Doxorubicin, 5-fluorouracil, cisplatin, and paclitaxel are the first-line …
treating various cancers. Doxorubicin, 5-fluorouracil, cisplatin, and paclitaxel are the first-line …