Biology of obesity: lessons from animal models of obesity

K Kanasaki, D Koya - BioMed Research International, 2011 - Wiley Online Library
Obesity is an epidemic problem in the world and is associated with several health problems,
including diabetes, cardiovascular disease, respiratory failure, muscle weakness, and …

[PDF][PDF] Animal models of obesity

J Speakman, C Hambly, S Mitchell, E Krol - Obesity Reviews, 2007 - researchgate.net
Background Obesity stems from a prolonged imbalance between the levels of energy intake
and expenditure, with the resultant surplus being stored as body lipids. Our understanding of …

The contribution of animal models to the study of obesity

J Speakman, C Hambly, S Mitchell… - Laboratory animals, 2008 - journals.sagepub.com
Obesity results from prolonged imbalance of energy intake and energy expenditure. Animal
models have provided a fundamental contribution to the historical development of …

Balancing ovulation and anovulation: integration of the reproductive and energy balance axes by neuropeptides

JJ Evans, GM Anderson - Human reproduction update, 2012 - academic.oup.com
BACKGROUND Because of the substantial energy demands of reproduction, the brain must
temper the fertility of individuals to match nutritional availability. Under-nutrition is associated …

Chronic increase of circulating galanin levels induces obesity and marked alterations in lipid metabolism similar to metabolic syndrome

NJ Poritsanos, TM Mizuno, ME Lautatzis… - International Journal of …, 2009 - nature.com
Objective: Galanin (GAL) has a role in the regulation of food intake by way of acting on the
central nervous system in rodents. High serum GAL levels have been observed in obese …

Feeding behaviour in galanin knockout mice supports a role of galanin in fat intake and preference

AC Adams, JC Clapham, D Wynick… - Journal of …, 2008 - Wiley Online Library
It has been widely suggested that saturated fat consumption has fuelled the current obesity
epidemic. Macronutrient choices appear to be important not only as potential factors …

Dietary fat stimulates endogenous enkephalin and dynorphin in the paraventricular nucleus: role of circulating triglycerides

GQ Chang, O Karatayev, R Ahsan… - American Journal …, 2007 - journals.physiology.org
The opioid peptides enkephalin (ENK) and dynorphin (DYN), when injected into the
hypothalamus, are known to stimulate feeding behavior and preferentially increase the …

Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge

EP Zorrilla, M Brennan, V Sabino, X Lu, T Bartfai - Physiology & behavior, 2007 - Elsevier
Galanin, a brain and pancreatic peptide with three receptor subtypes (GALR1, GALR2, and
GALR3), is hypothesized to participate in energy homeostasis and glucoregulation …

Effect of dietary fatty acid composition on food intake, triglycerides, and hypothalamic peptides

JR Barson, O Karatayev, V Gaysinskaya, GQ Chang… - Regulatory peptides, 2012 - Elsevier
While a high-fat diet when compared to low-fat diet is known to produce overeating and
health complications, less is known about the effects produced by fat-rich diets differing in …

Neuropeptide modulation of addiction: Focus on galanin

SG Genders, KJ Scheller, E Djouma - Neuroscience & Biobehavioral …, 2020 - Elsevier
Addiction is a chronic, relapsing disorder characterised by the use of a substance or act to
the point of compulsion. There are a number of medical treatments available for the …