The chromosomal sex of the embryo is established at fertilization. However, 6 weeks elapse
in humans before the first signs of sex differentiation are noticed. Sex differentiation involves …

In humans, reticularis cells of the adrenal cortex fuel the production of androgen steroids,
constituting the driver of numerous morphological changes during childhood. These steps …

The field of bioelectrochemistry continues to develop due to diverse applications ranging
from biosensors to biotechnology and biofuel cells. Accordingly, research understanding the …

Biological electron-exchange reactions are fundamental to life on earth. Redox reactions
underpin respiration, photosynthesis, molecular biosynthesis, cell signalling and protein …

Abstract Cytochrome P450 17A1 (CYP17A1) catalyzes 17α-hydroxylation and 17, 20-lyase
reactions with steroid hormones. Mice contain an orthologous Cyp17a1 enzyme in the …

Abstract Cytochrome b5 (cyt b5) is a small hemoprotein that plays a significant role in the
modulation of activities of an important steroidogenic enzyme, cytochrome P450 17α …

It has been recognized for> 50 years that cytochrome b 5 (b 5) stimulates some cytochrome
P450 (P450)–catalyzed oxidations, but the basis of this function is still not understood well …

Human cytochrome P450 17A1 is required for all androgen biosynthesis and is the target of
abiraterone, a drug used widely to treat advanced prostate cancer. P450 17A1 catalyzes …

Cytochrome b 5 (b 5) is known to stimulate some catalytic activities of cytochrome P450
(P450, CYP) enzymes, although mechanisms still need to be defined. The reactions most …

Human cytochrome P450 (CYP) enzymes play an important role in the metabolism of drugs,
steroids, fatty acids, and xenobiotics. Microsomal CYPs are anchored in the endoplasmic …